Evidence map›Paper›PMID 41761257›Full record

ArticleBMC oral health2026

Porphyromonas gingivalis-derived outer membrane vesicles travel from oral to distant organs via blood circulation in a time-dependent manner.

Congcong Lv, Kaikai Shi, Zixin Guo, Pingchan Luo, Zhe Wu, Pei Yu

Abstract read
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In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Congcong Lv *Department of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Kaikai Shi *Department of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Zixin GuoDepartment of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Pingchan LuoDepartment of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Zhe WuDepartment of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. zhewudentist@gzhmu.edu.cn.
Pei YuDepartment of Prosthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. 2019686028@gzhmu.edu.cn.

Funding

Guangzhou Medical University 02-410-2302190XMGuangzhou Municipal Science and Technology Bureau 2023A03J0326Guangzhou Municipal Science and Technology Bureau 2023A04J1190
6 · The paper itself

Abstract

backgroundPeriodontitis is closely related to a variety of systemic diseases. Porphyromonas gingivalis (P. gingivalis) is one of the key pathogens of periodontitis. The influence of P. gingivalis outer membrane vesicles (OMVs) on systemic diseases have become an emerging research topic. However, the kinetic distribution of P. gingivalis OMVs in vivo is still unknown.

methodsKinetic biodistribution of P. gingivalis OMVs in mice with or without periodontitis was analyzed by Near-infrared fluorescence imaging. Custom Ab-P. gingivalis OMVs were developed and verified for quantitative analysis of various organs. Systemic and liver inflammatory indexes of mice were explored by ELISA and blood routine tests.

resultsOur results showed that P. gingivalis OMVs mainly distributed to different systemic organs as time-dependent manner through blood circulation. The accumulation in liver and lung was particularly obvious at 6 h after administration, but lung signals was absent at 24 h. The distribution of P. gingivalis OMVs was associated with the destruction of periodontal tissue. Spatially, P. gingivalis OMVs were detected in the intercellular matrix and cytoplasm of target cells, promoting systemic and local inflammation.

conclusionThese findings advance our understanding of the distribution route of P. gingivalis OMVs in systemic, providing insights for developing new therapeutic strategies for patientis with periodontitis and systemic diseases.

Indexed as

Bacterial Outer MembranePeriodontitisPorphyromonas gingivalisAnimalsLiverMiceTime FactorsBlood circulationKinetic biodistributionOuter membrane vesiclesPeriodontitisPorphyromonas gingivalis

Identifiers

PMID41761257
PMCPMC13049830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.