ArticleBMC oral health2026
Polyacrylic Acid concentrations on biomimetic remineralization in artificial enamel lesions.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundThe study aimed to evaluate the effect of Polyacrylic Acid (PAA) concentration on the remineralization of artificial enamel lesions in a pH cycling (pHc) model in vitro, as well as the effect of different durations to the pHc.
methodsBovine enamel specimen were prepared and two artificial caries lesions were created with a demineralization solution (pH 4.95; 28 d) separated by varnish. Specimens were randomly assigned to three groups for different PAA concentrations (n = 40). One lesion in each specimen was etched (37% H3PO4, 5 s) and infiltrated with PAA (0.1, 1 or 10 mg/ml), the other lesion served as a non-treatment control (NTC). To obtain a baseline control (BL), specimens were cut perpendicularly to the lesions. The remaining halves (E) were exposed to pHc (21 h/d: pH = 7; 3 h/d: pH = 4.95) for either 28 d or 56 d (n = 20). The difference in integrated mineral loss between baseline and after pHc was analyzed using transverse microradiography (ΔΔZ = ΔZE—ΔZBL).
resultsAfter 28 days, lesions treated with 0.1 mg/ml and 1 mg/ml PAA showed significantly greater mineral gain than NTC (p < 0.05, Wilcoxon), while 10 mg/ml PAA showed no significant effect (p > 0.05). Prolonging pHc to 56 days did not yield significant differences between groups (p > 0.05, Kruskal–Wallis).
conclusionsLower concentrations of PAA seem to promote remineralization in the chosen pHc model.
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