Evidence map›Paper›PMID 41761152›Full record

ArticleBMC pediatrics2026

Behavioral and emotional problems and quality of life in Chinese children with Langerhans cell histiocytosis.

Shijie Li, Ying Li, Juan Du, Aimin Liang, Hongyun Lian, Honghao Ma, Rui Zhang

Abstract read
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In one paragraph

Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shijie LiDepartment of Child Health Care, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Ying LiDepartment of Psychosomatic Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Juan DuDepartment of Child Health Care, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Aimin LiangDepartment of Child Health Care, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Hongyun LianDepartment of Hematology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Honghao MaDepartment of Hematology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Rui ZhangDepartment of Hematology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishi Road, Xicheng District, Beijing, 100045, China. ruizh1973@126.com.

Funding

Beijing Natural Science Foundation No. 7232058, 7242053National Natural Science Foundation of China No.82070202 and 82141119the Capital's Funds for Health Improvement and Research 2022-2-1141
6 · The paper itself

Abstract

objectiveThis study intended to explore behavioral and emotional problems and quality of life, as well as their related factors in Chinese children with Langerhans cell histiocytosis (LCH).

methodsThis was a cross-sectional study. Subjects were included from April 2023 to September 2023. Child behavior checklist (CBCL), pediatric quality of life inventory™ version 4.0 (PedsQL

resultsA total of 120 children with LCH were included. Twenty-six (21.7%) children had behavioral and emotional problems. Age at diagnosis ≥ 4 years [odds ratio (OR) = 0.344, P = 0.022] and major caregiver with an educational level of junior college and above (OR = 0.314, P = 0.035) were independently associated with a lower possibility of achieving CBCL total problem score ≥ 35. Electronic product usage time ≥ 2 h per day (B=-6.024, P = 0.011) and caesarean section (B=-6.006, P = 0.012) were independently related to a lower total PedsQL

conclusionIn this study, 21.7% of Chinese children with LCH exhibit behavioral and emotional problems. Age at diagnosis < 4 years, major caregiver with an educational level of high school and below, electronic product usage time ≥ 2 h, caesarean section, and second-line treatment are related to behavioral and emotional problems and impaired quality of life in Chinese children with LCH. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Affective SymptomsChild Behavior DisordersHistiocytosis, Langerhans-CellProblem BehaviorQuality of LifeAdolescentChildChild, PreschoolChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansInfantMaleBehavioral and emotional problemsLangerhans cell histiocytosisPrevalenceQuality of lifeRisk factors

Identifiers

PMID41761152
PMCPMC13049716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.