Evidence map›Paper›PMID 41761148›Full record

Observational studyBMC pulmonary medicine2026

The relevance of sputum galectin-7 levels to clinical and prognostic factors in patients with chronic obstructive pulmonary disease: a prospective cohort study from China.

Wenqiang He, Xueping Li, Haining Huang, Zitong Tang, Junqing Zhu, Yuqiong Yang, Zizheng Chen, Chengyu Miao, Huajing Yang, Shanshan Zha and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03240315 (Establishment of Individualized Prediction System for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Based on Cloud Platform), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03240315 active not recruitingnot on this map

Establishment of Individualized Prediction System for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Based on Cloud Platform

TypeobservationalSponsorGuangzhou Institute of Respiratory DiseaseRan2016 to 2026Enrolled442ConditionsPulmonary Disease, Chronic Obstructive
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Wenqiang He *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Xueping Li *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Haining Huang *Nanshan School, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
Zitong Tang *Nanshan School, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
Junqing ZhuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Yuqiong YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Zizheng ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Chengyu MiaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Huajing YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Shanshan ZhaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Zifei ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Jiachun LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Zhenyu LiangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. 490458234@qq.com.
Rongchang ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. chenrc@vip.163.com.
Fengyan WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. 420343176@qq.com.

Funding

the grant of State Key Laboratory of Respiratory Disease SKLRD-Z-202317the National Key Research and Development Program of China 2017YFC1310600the National Natural Science Foundation of China 82200044the National Natural Science Foundation of China 82270044
6 · The paper itself

Abstract

objectiveGalectin-7, a β-galactoside-binding lectin involved in inflammation, immune regulation, and apoptosis, has been implicated in the development and progression of various lung diseases. Inflammation, immune dysregulation, and epithelial cell apoptosis are key pathophysiological mechanisms underlying chronic obstructive pulmonary disease (COPD). However, the clinical significance of galectin-7 in COPD remains unclear. This study aimed to investigate the association between sputum galectin-7 levels and the clinical characteristics and prognosis of patients with COPD.

methodsIn this prospective study, 150 patients with stable COPD and 50 healthy controls were enrolled. Demographic data, clinical parameters, and sputum samples were collected. Baseline galectin-7 concentrations in sputum supernatants were measured using an enzyme-linked immunosorbent assay (ELISA). Patients with COPD were followed for one year to document acute exacerbation events. Among COPD patients, Spearman correlation analysis and multivariable linear regression were performed to examine the associations between galectin-7 levels and clinical parameters or inflammatory markers, adjusting for sex, age, smoking status, and body mass index (BMI). Multivariable Poisson regression and logistic regression models were further applied to assess the relationship between galectin-7 levels and acute exacerbations within one year, with adjustment for the number of exacerbations in the previous year, sex, age, smoking status, BMI, and post-bronchodilator FEV1% predicted (Post-BD FEV1% pred).

resultsAfter adjustment in the analysis of covariance, galectin-7 levels were significantly lower in patients with GOLD III–IV than in healthy controls and patients with GOLD I–II (P < 0.05). Multivariable linear regression analyses indicated that galectin-7 levels were significantly associated with multiple clinical indicators and inflammatory markers. In the multivariable Poisson regression model, each 10 ng/mL increase in sputum galectin-7 was associated with a 15.7% reduction in the risk of acute exacerbations within one year (RR, 0.843; 95% CI, 0.716–0.973; P = 0.028). In the multivariable logistic regression model, each 10 ng/mL increase in sputum galectin-7 was associated with a 35.1% lower risk of frequent acute exacerbations within one year (OR, 0.649; 95% CI, 0.424–0.923; P = 0.029).

conclusionLower sputum galectin-7 levels are associated with later stages and an increased risk of future acute exacerbations in COPD, suggesting that galectin-7 may be a promising biomarker related to disease severity and prognosis.

trial registrationThis study was registered in the International Clinical Trials Registry (NCT03240315). Trial registration on July 31, 2017.

Indexed as

GalectinsPulmonary Disease, Chronic ObstructiveSputumAgedBiomarkersCase-Control StudiesChinaDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersGalectinsLGALS7 protein, humanBiomarkerChronic obstructive pulmonary diseaseClinical characteristicsPrognosisSputum galectin-7

Identifiers

PMID41761148
PMCPMC13049942

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