ArticleBMC infectious diseases2026
The impact of catheter replacement in patients with catheter-associated urinary tract infection: study protocol paper for a multicentre, non-inferiority randomized controlled trial (REPLACE).
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06936631 (REPLACE), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REPLACE: the Impact of Catheter Replacement in Patients With Catheter-associated Urinary Tract Infection
Who cites it
1 citing paper in PubMed.
- [Bacteriuria in patients with indwelling urinary catheters-when and how to treat? : Diagnosis, prevention and treatment of catheter-associated urinary tract infections].Urologie (Heidelberg, Germany) · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundCatheter-associated urinary tract infection (CAUTI) is the most common healthcare associated infection. Current guidelines state that catheters should be replaced in patients with CAUTI to hasten symptom resolution and to lower the risk of recurrence. However, the available literature is limited and there is significant practice variation globally. The aim of this study is to determine whether not changing the catheter during CAUTI treatment affects the recurrence-risk. METHODS AND ANALYSIS: The REPLACE study is a multicentre, non-inferiority- randomized controlled trial designed to assess whether retaining the urinary catheter in patients with CAUTI is non-inferior to replacement in terms of the risk of a recurrent CAUTI within 90 days. Secondary outcome measures include 30-day mortality, health-related quality of life, time to resolution of CAUTI symptoms, complications related to catheter replacement and healthcare and societal costs. Patients aged 18 years or older with an indwelling catheter (transurethral or suprapubic) and CAUTI are eligible. CAUTI is defined according to the Infectious Diseases Society of America (IDSA) criteria. Three hundred patient will be randomised 1:1 to catheter retention (intervention group) or replacement (control group). In the intervention group, the catheter is not replaced. In the control group the catheter will be replaced within 3 days after start of antibiotic therapy. The primary outcome (recurrent CAUTI within 90 days) will be assessed for non-inferiority (margin of 10%). DISCUSSION: This trial will address a critical evidence gap and may inform future guidelines regarding catheter management in CAUTI. If replacement is found to have no benefit, this could reduce unnecessary interventions, lower healthcare costs and material use, contribute to sustainability, and lessen the burden on both patients and healthcare organizations.
trial registrationRegistered at clinicaltrial.gov on 17 April 2025 with registration number: NCT06936631.
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