ArticleJournal of materials science. Materials in medicine2026
Effect of niosome formation with chitosan coating on the stability and absorption of orally administered vesicular ursolic acid.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Niosomes are known to improve the bioavailability of drugs. However, niosomes have drawbacks related to stability and absorption in the gastrointestinal tract. Chitosan coating on niosomes can increase their stability in gastrointestinal fluid and absorption after oral administration. This study aimed to evaluate the biopharmaceutical stability and oral absorption of chitosan-coated Ursolic acid niosomes in vivo. Niosomes Ursolic Acid (Nio-UA) were prepared using a thin-layer hydration method, and chitosan was added to produce Niosomes Ursolic Acid with chitosan coating (Nio-UA-CS). The stability of niosomes was evaluated by exposing them to simulated gastrointestinal fluid. The oral absorption and biodistribution were determined in vivo. The results showed that niosome formation increased UA solubility from 1.02 × 10
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