Evidence map›Paper›PMID 41760980›Full record

Trial reportClinical oral investigations2026

Effect of different material protocols on the control of dentin hypersensitivity: a split-mouth randomized controlled clinical trial.

Júlia Marques Martins, Maria Fernanda Ferreira Nogueira, Guilherme José Pimentel Lopes de Oliveira, Alexandre Coelho Machado, Paulo César de Freitas Santos Filho, Hugo Lemes Carlo, Carlos José Soares, Gisele Rodrigues da Silva

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Júlia Marques MartinsDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Maria Fernanda Ferreira NogueiraDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Guilherme José Pimentel Lopes de OliveiraDepartment of Periodontology and Implantology, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Alexandre Coelho MachadoDepartment of Operative Dentistry and Dental Materials, Technical School of Oral Health, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Paulo César de Freitas Santos FilhoFederal University of Uberlândia School of Dentistry, Avenida Pará, 1720, Bloco 4L, Anexo A, Sala 4LA33, Campus Umuarama, Uberlândia , MG, 38405-320, Brazil.
Hugo Lemes CarloFederal University of Uberlândia School of Dentistry, Avenida Pará, 1720, Bloco 4L, Anexo A, Sala 4LA33, Campus Umuarama, Uberlândia , MG, 38405-320, Brazil.
Carlos José SoaresFederal University of Uberlândia School of Dentistry, Avenida Pará, 1720, Bloco 4L, Anexo A, Sala 4LA33, Campus Umuarama, Uberlândia , MG, 38405-320, Brazil.
Gisele Rodrigues da SilvaFederal University of Uberlândia School of Dentistry, Avenida Pará, 1720, Bloco 4L, Anexo A, Sala 4LA33, Campus Umuarama, Uberlândia , MG, 38405-320, Brazil. giselerosilva@ufu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the efficacy of three desensitizing protocols for dentin hypersensitivity (DH) pain control and their impact on oral health–related quality of life (OHRQoL) up to 180 days. MATERIALS AND

methodsIn this randomized controlled split-mouth clinical trial, 33 participants (99 teeth) were randomized and treated; 31 participants (93 teeth) were analyzed (mITT). Participants received three protocols: GLU: 3% potassium nitrate + glutaraldehyde/HEMA desensitizer (control); GAS: 3% potassium nitrate + glutaraldehyde/HEMA desensitizer + universal adhesive; and GAR: 3% potassium nitrate + glutaraldehyde/HEMA desensitizer + universal adhesive + bulk-fill flowable resin. Pain intensity was recorded using the Numeric Rating Scale (NRS; 0–10) after standardized air-blast and tactile stimuli at baseline, immediately after intervention, and at 7, 30, 90, and 180 days. OHRQoL was assessed using OHIP-14 at baseline, 90, and 180 days.

resultsNRS scores decreased over time for both stimuli (air-blast: p < 0.001; tactile: p < 0.001). No differences were observed among protocols (air-blast: p = 0.910; tactile: p = 0.681) and no time × protocol interaction was detected (air-blast: p = 0.341; tactile: p = 0.738). OHIP-14 scores improved at 90 and 180 days versus baseline (p < 0.001).

conclusionsThe three protocols produced comparable patient-centered outcomes, indicating that adding adhesive and resin steps to potassium nitrate + glutaraldehyde/HEMA does not enhance DH pain control or OHRQoL up to 180 days. CLINICAL RELEVANCE: Increasing complexity with adhesive and resin steps was not associated with superior patient-centered outcomes within 180 days. CLINICAL TRIAL REGISTRATION NUMBER: RBR-109h3wcv.

Indexed as

Dentin Desensitizing AgentsDentin SensitivityAdultFemaleGlutaralHumansMaleMethacrylatesMiddle AgedNitratesPain MeasurementPotassium CompoundsQuality of LifeTreatment OutcomeDentin Desensitizing AgentsGlutaralhydroxyethyl methacrylateMethacrylatesNitratesPotassium Compoundspotassium nitrateDental sensitivityDentin adhesivesPain assessmentQuality of life

Identifiers

PMID41760980
PMCPMC12948845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.