Evidence map›Paper›PMID 41760906›Full record

ArticleNature immunology2026

Sparcl1 mitigates abdominal aortic aneurysm through inhibiting lymphangiogenesis-mediated TLS formation.

Mei-Hua Chen, Yi-Jie Hua, Yan Li, Yu Lei, Si-Yuan Zhou, Xi-De Hu, Dong-Hua Hu, Zhi-Hui Dong, Yan Lu, Tao Zhuang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. BACH2 the future.Nature immunology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mei-Hua Chen *Institute of Metabolism and Regenerative Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Jie Hua *Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-8513-5382
Yan LiDepartment of Cardiology, RuiJin Hospital/LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liyan1987123@126.com.ORCID http://orcid.org/0009-0005-1506-6402
Yu LeiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Si-Yuan ZhouDepartment of Vascular Surgery, Zhongshan Hospital, and Center for Vascular Surgery and Wound Care, Jinshan Hospital, Fudan University, Shanghai, China.
Xi-De HuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Dong-Hua HuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhi-Hui DongDepartment of Vascular Surgery, Zhongshan Hospital, and Center for Vascular Surgery and Wound Care, Jinshan Hospital, Fudan University, Shanghai, China. dzh926@126.com.ORCID http://orcid.org/0000-0002-3754-2458
Yan LuInstitute of Metabolism and Regenerative Medicine, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. luyan5011@shsmu.edu.cn.ORCID http://orcid.org/0000-0003-3468-2241
Tao ZhuangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. zhuangtao5217@163.com.ORCID http://orcid.org/0000-0001-9139-193X
Cheng-Chao RuanDepartment of Physiology and Pathophysiology, State Key Laboratory of Medical Neurobiology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, Fudan University, Shanghai, China. ruancc@fudan.edu.cn.ORCID http://orcid.org/0000-0001-5229-9428

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32271233National Natural Science Foundation of China (National Science Foundation of China) 82500512National Natural Science Foundation of China (National Science Foundation of China) 92368105
6 · The paper itself

Abstract

Vascular tissue-resident macrophages (VRMs) maintain immune balance in blood vessels, but their role in abdominal aortic aneurysm (AAA) development remains unclear. Here we demonstrated that a specific group of VRMs located in the adventitia marked by expression of Lyve1, protected against AAA by secreting the extracellular matrix protein Sparcl1 (Sc1). Deletion of Sc1 in VRMs promoted dysfunctional lymphangiogenesis and led to the formation of tertiary lymphoid structures (TLSs), thereby accelerating AAA progression. Mechanistically, the calcium-binding domain of Sc1 acted as a trap for the growth factor FGF2, inhibiting FGF2-mediated dysfunctional lymphangiogenesis and expression of genes associated with TLS formation. A therapeutic peptide derived from Sc1 (Spa17) mitigated AAA progression in several AAA models. Our findings reveal that VRM-derived Sc1 has a protective role in AAA and identify a potential therapeutic approach.

Indexed as

Aortic Aneurysm, AbdominalCalcium-Binding ProteinsExtracellular Matrix ProteinsLymphangiogenesisMacrophagesAnimalsDisease Models, AnimalHumansMaleMembrane Transport ProteinsMiceMice, Inbred C57BLMice, KnockoutVesicular Transport ProteinsCalcium-Binding ProteinsExtracellular Matrix ProteinsLYVE1 protein, mouseMembrane Transport ProteinsVesicular Transport Proteins

Identifiers

PMID41760906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.