Evidence map›Paper›PMID 41760905›Full record

ArticleNature immunology2026

TOX drives CD4

Brianna Naizir, Andrew C Scott, Paul Zumbo, Simon Grassmann, Joe N Frost, Joseph C Sun, Doron Betel, Andrea Schietinger

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The dual role of TOX in regulating TNature immunology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brianna NaizirGerstner Sloan Kettering Graduate School, Sloan Kettering Institute, New York, NY, USA. naizirb@sloankettering.edu.ORCID http://orcid.org/0009-0009-9492-7440
Andrew C ScottImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Paul ZumboDepartment of Systems and Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Simon GrassmannImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8336-3418
Joe N FrostImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5946-6062
Joseph C SunGerstner Sloan Kettering Graduate School, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0000-0001-8062-9033
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8006-7752
Andrea SchietingerGerstner Sloan Kettering Graduate School, Sloan Kettering Institute, New York, NY, USA. schietia@mskcc.org.ORCID http://orcid.org/0000-0003-3644-1687

Funding

Autoimmune Stem-like CD8 T cells in Type 1 DiabetesR01AI173249 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Schietinger · 2023 to 2026
$3.5M
TOX-driven CD8 T cell differentiation and dysfunction in tumorsR01CA269733 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Schietinger · 2023 to 2026
$2.4M
Cancer Research Institute (CRI) STAR AwardJDRF JDRF SRA-2023-1410-S-BNCI NIH HHS R01 CA269733NIAID NIH HHS R01 AI173249U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30 CA08748U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA269733U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI173249
6 · The paper itself

Abstract

TOX is a nuclear factor critical for thymic development of CD4

Indexed as

Autoimmune DiseasesCD4-Positive T-LymphocytesHomeodomain ProteinsNeoplasmsTh1 CellsAnimalsAutoimmunityCD8-Positive T-LymphocytesCell DifferentiationFemaleHigh Mobility Group ProteinsHumansInterferon-gammaMiceMice, Inbred C57BLMice, KnockoutHigh Mobility Group ProteinsHomeodomain ProteinsInterferon-gammaRhox8 protein, mouseTOX protein, human

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.