ArticleCommunications biology2026
Bone marrow endosteum houses Hedgehog-susceptible Dlx5-expressing osteoblast precursor cells.
Keita Kondo, Yuki Matsushita, Shion Orikasa, Yuta Nakai, Aiko Kuroda, Shinsuke Ohba, Wanida Ono, Noriaki Ono
Abstract read
In one paragraphArticle in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Keita Kondo *Department of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yuki Matsushita *Department of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. yukimatsushita@nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0001-9577-3249 Yuta NakaiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Aiko KurodaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shinsuke OhbaDepartment of Tissue and Developmental Biology, Graduate School of Dentistry, Osaka University, Osaka, Japan.
Wanida OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Funding
Skeletal stem cell plasticity in craniofacial bone diseases.R35DE034348 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Noriaki Ono · 2024 to 2026
$3.1MCraniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2MDynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1MPharmacological rescue of tooth eruption disordersR01DE030416 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Wanida Ono · 2023 to 2026
$1.9MDental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9MMEXT | Japan Science and Technology Agency (JST) JPMJFR2111MEXT | Japan Society for the Promotion of Science (JSPS) JP23K21487MEXT | Japan Society for the Promotion of Science (JSPS) JP24KK0168MEXT | Japan Society for the Promotion of Science (JSPS) JP25H01073NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01 DE030630NIDCR NIH HHS R35 DE034348U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE026666U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE029181U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE030416U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE030630U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R35DE034348
6 · The paper itselfAbstract
The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5
Indexed as
Bone Marrow CellsHedgehog ProteinsHomeodomain ProteinsOsteoblastsStem CellsAnimalsCell DifferentiationMiceOsteogenesisDlx5 protein, mouseHedgehog ProteinsHomeodomain Proteins
Identifiers
PMID41760892
PMCPMC13065780
What OpenQuestion holds
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