Evidence map›Paper›PMID 41760805›Full record

ReviewThe EMBO journal2026

Molecular evolution of animal aging.

Daniel H Nussey, Fabrizio d'Adda di Fagagna, Allison J Bardin, Helen M Blau, Anne Brunet, Dmitry V Bulavin, Longhua Guo, Eiji Hara, Jan Philipp Junker, Vera Gorbunova and 11 more

Abstract readReview
In one paragraph

Review in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Daniel H NusseyInstitute of Ecology and Evolution, The University of Edinburgh School of Biological Sciences, Edinburgh, Edinburgh, UK.
Fabrizio d'Adda di FagagnaIFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.
Allison J BardinInstitut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, Paris, 75005, France.ORCID http://orcid.org/0000-0002-0200-4465
Helen M BlauBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford School of Medicine, Stanford, CA, 94305-5175, USA.
Anne BrunetGlenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA, USA.
Dmitry V BulavinInstitute for Research on Cancer and Aging of Nice (IRCAN); Université Côte d'Azur, INSERM; CNRS, Nice, France.
Longhua GuoDepartment of Molecular Integrative Physiology, Department of Cell Developmental Biology, Institute of Gerontology, Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
Eiji HaraDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0001-7821-3960
Jan Philipp JunkerMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin Institute for Medical Systems Biology, Berlin, Germany.ORCID http://orcid.org/0000-0002-2826-8290
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-8979-0333
Maria MittelbrunnCentro de Biología Molecular, Consejo Superior de Investigaciones Científicas, CSIC-UAM, Madrid, Spain.ORCID http://orcid.org/0000-0003-3487-8762
Michael ReraUniversité Paris Cité, Biologie Fonctionnelle et Adaptative, Paris, France.ORCID http://orcid.org/0000-0002-6574-6511
Jane ReznickCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, University of Cologne, Cologne, Germany.
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-3400-538X
Björn SchumacherCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6097-5238
Emma C TeelingSchool of Biology and Environmental Science, University College Dublin, Dublin, Ireland.
Dario Riccardo ValenzanoLeibniz Institute on Aging, Fritz Lipmann Institute (FLI), Jena, Germany.ORCID http://orcid.org/0000-0002-8761-8289
Jing YeDepartment of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Maximina H YunChinese Institutes for Medical Research, Beijing, China.ORCID http://orcid.org/0000-0001-9019-2453
George A GarinisInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece. garinis@imbb.forth.gr.ORCID http://orcid.org/0000-0002-3200-5004
Eric GilsonInstitute for Research on Cancer and Aging of Nice (IRCAN); Université Côte d'Azur, INSERM; CNRS, Nice, France. eric.gilson@univ-cotedazur.fr.ORCID http://orcid.org/0000-0001-5738-6723

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Turning back biological clock: mechanisms of age reversal in a whole organismDP2AG093207 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUO, LONGHUA · 2024 to 2024
$1.4M
Imaging spatial transcriptome at single cell resolution to study eye regeneration in old ageR21AG084959 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUO, LONGHUA · 2023 to 2025
$624k
NIA NIH HHS DP2 AG093207NIA NIH HHS P01 AG047200NIA NIH HHS P30 AG024824NIA NIH HHS R21 AG084959
6 · The paper itself

Abstract

Comparative biology plays a crucial role in uncovering fundamental biological mechanisms and providing evolutionary models for their variation. This approach is particularly valuable for studying aging, given the remarkable diversity in aging trajectories across the tree of life. Many evolutionary theories of aging were proposed well before the discovery of the molecular mechanisms involved, and they remain largely theoretical. Moreover, the growing number of model organisms and the expanding array of experimental and theoretical approaches used to study aging have often remained compartmentalized. As a result, integrating these diverse insights into a unified framework has become increasingly important. As a step toward this goal, this field perspective outlines general biological mechanisms that help explain the variability in aging patterns and longevity across the animal kingdom.

Indexed as

AgingEvolution, MolecularAnimalsBiological EvolutionLongevityAgingDevelopmentEnvironmentEvolutionSenescence

Identifiers

PMID41760805
PMCPMC13043702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.