Evidence map›Paper›PMID 41760795›Full record

SynthesisLasers in medical science2026

Is photobiomodulation an effective preventive strategy for oral mucositis in patients with hematologic diseases undergoing chemotherapy?: A systematic review of randomized controlled trials.

Maria Gabriella Apolinário Xavier, Alícia Marcelly Souza de Mendonça Silva, Guilherme Rodrigues Wanderley de Oliveira, Allan Vinícius Martins-de-Barros, Stefânia Jeronimo Ferreira, Raylane Farias de Albuquerque, Igor Henrique Morais Silva, Lucas Nascimento Ribeiro

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Gabriella Apolinário XavierResidents in Hospital Dentistry with a Focus on Oncology at the Pernambuco Cancer Hospital, Recife, Brazil.
Alícia Marcelly Souza de Mendonça SilvaResidents in Hospital Dentistry with a Focus on Oncology at the Pernambuco Cancer Hospital, Recife, Brazil.
Guilherme Rodrigues Wanderley de OliveiraResidents in Hospital Dentistry with a Focus on Oncology at the Pernambuco Cancer Hospital, Recife, Brazil.
Allan Vinícius Martins-de-BarrosUniversity of Pernambuco, School of Dentistry of Arcoverde, Arcoverde, Pernambuco, Brazil.
Stefânia Jeronimo FerreiraUniversity of Pernambuco, School of Dentistry of Arcoverde, Arcoverde, Pernambuco, Brazil.
Raylane Farias de AlbuquerqueDepartment of Dentistry at the Pernambuco Cancer Hospital, Recife, Brazil.ORCID http://orcid.org/0000-0002-8250-4469
Igor Henrique Morais SilvaDepartment of Dentistry at the Pernambuco Cancer Hospital, Recife, Brazil.ORCID http://orcid.org/0000-0002-7559-2608
Lucas Nascimento RibeiroUniversity of Pernambuco, School of Dentistry of Arcoverde, Arcoverde, Pernambuco, Brazil. lucas.ribeiro@upe.br.ORCID http://orcid.org/0000-0002-9284-749X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose to conduct a systematic review to assess whether photobiomodulation is effective in preventing oral mucositis in patients with hematologic diseases undergoing chemotherapy. Methods: A systematic search was conducted in the Embase, Medline/PubMed, Cochrane, Scopus, Web of Science and LILACS databases. The strategy included selected randomized clinical trials that evaluated the prevention of oral mucositis, directly comparing the use of photobiomodulation for chemotherapy-induced oral mucositis in patients with hematologic diseases with alternative non-laser therapies. The risk of bias in the studies was assessed using the Cochrane Collaboration’s tool for assessing risk of bias and the certainty of evidence was assessed using GRADE. Results: After applying all predetermined criteria, six randomized clinical trials, dated between 1997 and 2024, were included. A total of 200 patients were evaluated, with all six studies using the red wavelength, with only one study using a combination with the infrared wavelength. It was observed that photobiomodulation can be effective in preventing oral mucositis, reducing its frequency. Furthermore, a reduction in pain intensity and an improvement in quality of life were also identified. Conclusion: The use of photobiomodulation shows promising results in preventing oral mucositis, consequently reducing the frequency and pain of patients with hematologic diseases undergoing chemotherapy.

Indexed as

Antineoplastic AgentsHematologic DiseasesLow-Level Light TherapyStomatitisHumansQuality of LifeRandomized Controlled Trials as TopicAntineoplastic AgentsChemotherapyHematologic diseasesOral mucositisPhotobiomodulation

Identifiers

PMID41760795
PMCPMC12948774

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.