Evidence map›Paper›PMID 41760693›Full record

ArticleScientific reports2026

Identification and validation of prognostic genes associated with integrative stress response in lung adenocarcinoma and construction of the risk models.

Jianjun Fu, Yunming Tao, Wu Liu

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jianjun FuDepartment of Cardiothoracic Surgery, Gaoxin Branch of The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yunming TaoDepartment of Cardiothoracic Surgery, Gaoxin Branch of The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wu LiuDepartment of Cardiothoracic Surgery, Gaoxin Branch of The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. 18379147896@163.com.

Funding

In-Hospital Funding Project of the Gaoxin Branch of The First Affiliated Hospital of Nanchang University ky2023003In-Hospital Funding Project of the Gaoxin Branch of The First Affiliated Hospital of Nanchang University KYZZ202503The Professional and Technical Backbone Project of Gaoxin Branch of the First Affiliated Hospital of Nanchang University GXGG20247205
6 · The paper itself

Abstract

​Integrated stress response (ISR) genes are implicated in lung adenocarcinoma (LUAD) prognosis, but their clinical utility remains unexplored. This study aims to identify ISR-related prognostic genes and construct a risk model for LUAD survival prediction.​ LUAD transcriptomic and clinical data were retrieved from public databases. ISR-related genes (ISR-RGs) were screened via differential expression and regression analysis. A risk model and a nomogram integrating clinical indicators were built and validated. Functional enrichment, immune cell infiltration, and RT-qPCR in clinical samples were performed.​​​ Five prognostic genes (AGER, GPX3, CCNA2, KCNK3, and CHEK1) were identified. High-risk patients exhibited poorer survival. The nomogram was able to forecast the survival of LUAD well. Genes were functionally linked to cell cycle and DNA replication and correlated with immune cells (e.g., CCNA2 positively with CD4⁺ T cells [cor = 0.52]; CHEK1 negatively with memory B cells [cor = - 0.40]). RT-qPCR confirmed dysregulation: AGER, GPX3, and KCNK3 downregulated and CHEK1 and CCNA2 upregulated versus controls. The five prognostic genes pertinent to both LUAD and ISR were identified, and a risk model was constructed for the good prediction of LUAD survival, which offered a fresh outlook for alleviating the poor prognosis of LUAD.

Indexed as

Adenocarcinoma of LungBiomarkers, TumorIntegrated Stress ResponseLung NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansNomogramsPrognosisTranscriptomeBiomarkers, TumorImmune microenvironmentIntegrated stress responseLung adenocarcinomaNomogramPrognosis

Identifiers

PMID41760693
PMCPMC13049088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.