ArticleScientific reports2026
Application of simultaneous multi-slice accelerated readout-segmented echo planar diffusion-weighted imaging in assessing tumor response to neoadjuvant therapy in locally advanced rectal cancer.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To explore the role of simultaneous multi-slice (SMS) accelerated readout-segmented echo planar (RESOLVE) diffusion-weighted imaging (DWI) in assessing tumor response to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). 42 clinically diagnosed LARC patients, who received nCRT were prospectively enrolled. All patients underwent pre-operative rectal MRI, including both RESOLVE and SMS-RESOLVE DWIs with respective scan time of 3min50s and 1min47s. Regions of interest covering the three largest slices of residual lesions were drawn independently by two radiologists to calculate mean ADC values. Two radiologists also independently determined T stage (ymrT) and tumor regression grade (mrTRG) using a 5-point grading system on T2WI with and without SMS-RESOLVE DWI on pre-operative MRI. According to the pathological data, patients were grouped into pathological complete response (pCR) and non-pCR, good response and poor response, low T stage and high T stage groups. The diagnostic performance of SMS-RESOLVE DWI was analyzed and compared with RESOLVE DWI and T2WI. The interobserver agreement was both excellent for ADC value measurements in RESOLVE (ICC = 0.908) and SMS-RESOLVE (ICC = 0.894) DWIs between two readers. Patients who achieved pCR or good response showed significantly higher ADC values than non-pCR (1.459 ± 0.173 vs. 1.205 ± 0.107*10
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