ArticleIn vivo (Athens, Greece)
Protective Effect of Exercise Training Against Age-induced Cerebral Microvascular Rarefaction: VEGF/Flk-1/PI3K/Akt Signaling and GLUT1 Expression.
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
BACKGROUND/
aimAge-related cerebral microvascular loss is associated with reduced angiogenesis and leads to inadequate tissue perfusion in the brain. Vascular endothelial growth factor (VEGF), crucial for angiogenesis, declines with age. Exercise enhances microvascular density and blood flow, promoting brain health. The specific mechanisms underlying exercise-induced angiogenesis in aging brains remain unclear. This study investigated the impact of exercise on microvessel density, tissue perfusion, and VEGF-angiogenic signaling in aging brains. MATERIALS AND
methodsMale rats were divided into three groups: an age-matched control, a sedentary control, and an exercise-trained group, which underwent swimming exercise. Regional cerebral tissue perfusion (CTP) was assessed in an
resultsMicrovessel density and regional CTP in the sedentary control group were significantly reduced compared to the age-matched control group. The exercise-trained group demonstrated substantial increases in microvessel density and regional CTP compared to the sedentary control group. An increase in GLUT1 in the exercise group indicates microvascular metabolic restoration. VEGF angiogenic protein levels were significantly decreased in the sedentary control group compared to the age-matched control group; however, exercise training significantly increased these protein levels relative to the sedentary control group. Furthermore, we discovered a strong and significant positive correlation among the microvessel density, regional CTP, and VEGF angiogenic proteins across the three groups.
conclusionSwimming exercise training may protect against age-induced cerebral microvascular loss and insufficient brain tissue perfusion through the VEGF-mediated angiogenic signaling cascade. The increase in GLUT1 indicates restored structural and metabolic endothelial function in the aging brain.
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