ArticleIn vivo (Athens, Greece)
Poly-lactic Acid Dermal Filler Enriched With InCube
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPoly-Lactic acid (PLA) fillers are widely used for facial and body volume restoration because of their collagen-stimulating properties. However, early inflammation, oxidative stress, and variable long-term remodeling remain as concerns. Vitamin C and glutathione support collagen synthesis and redox homeostasis but degrade rapidly in conventional systems. This study evaluated a PLA filler incorporating Ethyl ascorbic acid (Vitamin C) and glutathione stabilized within an InCube MATERIALS AND
methodsPLA-IC were prepared by combining PLA microspheres with microlattice-encapsulated vitamin C and glutathione. Scanning and transmission electron microscopy and selected-area electron diffraction were used to characterize particle morphology and structure. Antioxidant stability was examined using high-performance liquid chromatography and DPPH radical-scavenging assays during long-term storage.
resultsMicrolattice encapsulation preserved vitamin C and glutathione for 277 days and maintained strong DPPH-scavenging activity for up to 200 days.
conclusionMicrolattice-based incorporation of vitamin C and glutathione enhances the antioxidants stability and overall biostimulatory performance of PLA filler. Compared with conventional PLA, PLA-IC demonstrated improved volume retention, increased collagen formation, and a more controlled tissue response, indicating potential advantages for aesthetic applications and warranting clinical evaluation of safety and efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.