Evidence map›Paper›PMID 41760312›Full record

ArticleIn vivo (Athens, Greece)

The Effect of

Erdi Gürbüz, Abdo A Elfiky, Nusret Ök, Aylin Köseler

Abstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Associations ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erdi GürbüzDepartment of Orthopedics, Pamukkale University Faculty of Medicine, Denizli, Türkiye.
Abdo A ElfikyDepartment of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
Nusret ÖkDepartment of Orthopedics, Pamukkale University Faculty of Medicine, Denizli, Türkiye.
Aylin KöselerDepartment of Biophysics, Pamukkale University Faculty of Medicine, Denizli, Türkiye akoseler@pau.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTramadol, a centrally acting analgesic, is widely used in postoperative pain management. This study investigates the relationship between PATIENTS AND

methodsA total of 210 participants, including 110 TKA patients and 100 healthy controls, were enrolled.

resultsThe extensive metabolizer (EM) phenotype was the most common in the patient group (78.2%). Significant correlations were observed between VAS score changes and

conclusionThe

Indexed as

Arthroplasty, Replacement, KneeCytochrome P-450 CYP2D6Polymorphism, GeneticPostoperative PainTramadolAgedAllelesAnalgesics, OpioidFemaleGenotypeHumansMaleMiddle AgedPain MeasurementTreatment OutcomeAnalgesics, OpioidCytochrome P-450 CYP2D6TramadolCYP2D6pain managementpharmacogenomicstotal knee arthroplastytramadol

Identifiers

PMID41760312
PMCPMC12949914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.