Observational studyIn vivo (Athens, Greece)
Seroepidemiological Observational Study in Total and Neutralizing Antibodies to SARS-CoV-2 Among Primary Care Patients in Crete, Greece.
Observational study in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe current study aimed to assess the levels of total IgG antibodies against the spike (S) and nucleocapsid (N) proteins of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the neutralizing antibodies (nAbs) in a population of Crete, Greece. PATIENTS AND
methodsIn total, 1,061 participants with 2,081 follow-up measurements during May-December 2022, from eight different primary healthcare facilities, were categorized into four groups, based on vaccination and illness status. Blood samples were collected and processed to measure anti-S, anti-N and neutralizing antibodies. Based on specific cutoff values and using non-parametric methods, antibody levels were compared between different categories or disease/vaccination of SARS-CoV-2.
resultsThe proportion of participants who had been infected was higher among the unvaccinated. Additionally, an increase in the number of vaccine doses administered resulted in a noteworthy reduction in the frequency of illness, with proportions decreasing from 69.2% among those who were not vaccinated or 83.1% among those vaccinated 1-2 times to 21.6% among those vaccinated 4+ times (
conclusionThis population-based seroepidemiological study underscores the synergistic impact of vaccination and natural infection in sustaining elevated antibody levels during the Omicron period. The findings emphasize the importance of continuous immunological surveillance within primary healthcare settings to identify individuals at risk of declining immunization and to inform evidence-based booster vaccination strategies, thereby enhancing preparedness and resilience against future pandemic responses.
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