ArticleSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi2026
[Fiber photometry-based analysis of transcranial magneto-acoustic electrical stimulation effects on synaptic plasticity in the hippocampal CA1 region of APP/PS1 mice].
Article in Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial magneto-acoustic electrical stimulation (TMAES) is a non-invasive novel neuromodulation technique based on the magneto-acoustic coupling effect. In this study, we employed APP/PS1 transgenic mice as an experimental model, targeting the hippocampus. Cognitive function was assessed through behavioral tests, while neuronal morphology was examined using hematoxylin-eosin and Golgi staining. Additionally, fiber photometry was utilized to measure calcium transient intensity in the CA1 region. By investigating the effects of TMAES on synaptic plasticity in the hippocampus, we aimed to elucidate its potential regulatory mechanisms in improving cognitive function in AD mice. Behavioral results showed that the cognitive and memory abilities of mice in the AD+sham group were significantly lower than those in the WT+sham group, while TMAES intervention could significantly improve the cognitive function of mice in the AD+TMAES group. Morphological detection indicated that the number of pyramidal neurons and the density of dendritic spines in the hippocampal CA1 region of the AD+sham group were decreased, with an increased proportion of immature spines; all the above indicators were significantly improved after TMAES intervention. Fiber photometric detection revealed that the calcium activity and calcium amplitude of neurons in the CA1 region of the AD+TMAES group were significantly enhanced compared with those of the AD+sham group. Pearson correlation analysis showed that cognitive level was positively correlated with calcium amplitude, dendritic spine density, and mature spine proportion. Meanwhile, calcium amplitude was positively correlated with dendritic spine density and mature spine proportion. Therefore, TMAES may alleviate the damage to synaptic plasticity in the hippocampal CA1 region of APP/PS1 mice by regulating the function of calcium ion channels, thereby improving cognitive impairment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.