SynthesisMedicine2026
Follicular adenomatoid odontogenic tumor in adolescents: A systematic review of tooth-preserving management and a consecutive case report.
Synthesis in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
backgroundThe conventional management of follicular adenomatoid odontogenic tumor (AOT) involves the extraction of the associated impacted tooth. This systematic review incorporating a consecutive case aims to evaluate the feasibility and outcomes of a conservative, tooth-preserving strategy for follicular AOT in adolescents.
methodsA systematic search was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines across multiple databases (PubMed/MEDLINE, Embase, Web of Science, Scopus, CENTRAL) and trial registries from inception to August 15, 2025. Studies reporting on tooth-preserving management of histopathologically confirmed follicular AOT were included. A consecutive case of a 15-year-old female with a follicular AOT in the mandible affecting tooth #44 was incorporated and analyzed alongside the extracted data.
resultsThe review included 7 studies (7 cases) from the literature, which were pooled with the present case for a total of 8 patients (mean age: 14.1 years). All cases successfully retained the involved tooth with no recurrence reported during a mean follow-up of 23.1 months (range: 9-48 months). Primary treatment involved enucleation/curettage in 7 cases and marsupialization in one. Orthodontic traction was used to guide eruption in 7 teeth, while 1 tooth (the present case) erupted spontaneously following space maintenance. Factors associated with success included adolescent age, well-defined lesion borders, and teeth at favorable developmental stages (Nolla stage VIII-IX).
conclusionThis systematic review demonstrates that intentional tooth preservation is a viable management strategy for selected cases of follicular AOT in adolescents. The approach successfully avoids permanent tooth loss without increasing the risk of recurrence in the short-to-mid term, aligning with the benign biology of AOT. Key factors for success are identified to guide case selection. Nevertheless, long-term follow-up is essential to confirm the durability of these outcomes, and future prospective studies with larger cohorts are warranted to strengthen the evidence base.
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