ArticleMedicine2026
Causal relationship between obesity and diabetic neuropathy: A 2-sample Mendelian randomization study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
A growing body of evidence suggests a potential correlation between obesity and diabetic neuropathy (DN), but the causal nature of this relationship remains uncertain. We conducted a Mendelian randomization (MR) analysis to investigate the causal relationship between obesity and DN. Independent single nucleotide polymorphisms strongly associated with DN were identified from genome-wide association studies. Summary statistics for body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were also obtained from genome-wide association studies datasets. The causal effects were estimated using inverse-variance weighted analysis, MR-Egger regression, and weighted median estimation. Sensitivity analyzes were performed to assess the robustness of the findings. Inverse-variance weighted analysis revealed significant negative associations of BMI (P = .0006, OR = 0.809, 95% CI: 0.716-0.913), WC (P = .008, OR = 0.792, 95% CI: 0.665-0.943), and HC (P = .032, OR = 0.871, 95% CI: 0.768-0.988) with DN risk. No significant association was observed for WHR (P = .425, OR = 0.954, 95% CI: 0.849-1.071). After Bonferroni correction (α = 0.0125), there was a statistically significant relationship between BMI and DN (P ≤ .0125), indicating a causal relationship. However, the causal relationships between WC, HC, WHR, and DN were not statistically significant, with P-values all > .0125. However, the OR value of MR analysis is close to 1, indicating that BMI may have a slight protective effect on the risk of DN.
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