ArticleMedicine2026
Global research trends and hotspots in mesenchymal stem cell applications for bone regeneration: A bibliometric and visualized analysis.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeThis study aims to perform a bibliometric analysis of mesenchymal stem cells in relation to bone regeneration from 2005 to 2024. The objective is to identify emerging research hotspots and elucidate collaborative networks within the field.
methodsData were extracted from the Web of Science Core Collection on April 20, 2025. Both qualitative and quantitative analyses assessed publication trends, funding sources, journals, authors, institutions, and countries. Visualization and mapping of keywords, collaborations, and co-citation patterns were performed using CiteSpace and Bibliometrix.
resultsA total of 9441 articles were published from 2005 to 2024. Leading journals included Biomaterials, Acta Biomaterialia, and Journal of Biomedical Materials Research Part A. Liu Y emerged as the most prolific author with 167 publications and 5720 citations. China, along with Shanghai Jiao Tong University, ranked first in both national and institutional output. Core collaborations were observed between China, the USA, South Korea, and Germany. Prominent keywords included "osteogenic differentiation," "mesenchymal stem cells," "bone regeneration," "in vitro," and "scaffolds."
conclusionThis study offers a systematic analysis of the literature on mesenchymal stem cells in bone regeneration. Biomaterials is identified as the most influential journal in this field, with China, Shanghai Jiao Tong University, and Liu Y leading the research output. Key research hotspots include bone healing, bone metabolism, nanomaterials, and dynamics, while cutting-edge areas such as mitochondrial function, miR-21-5p, cellular senescence, exosomes, extracellular vesicles, and 3D printing are emerging as significant research directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.