ArticleThe Angle orthodontist2026
Comparison of conventional and self-adhesive orthodontic bonding systems in white spot lesion formation: an in vitro confocal Raman microscopy analysis.
Article in The Angle orthodontist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Objectives: To compare the susceptibility of enamel to white spot lesion formation following the application of two orthodontic bonding protocols: a conventional three-step adhesive system and a two-step self-adhesive system with primer integrated into the resin. Materials and Methods: Thirty extracted premolars were randomly allocated to two groups: Transbond XT (three-step system) and GC Ortho Connect (two-step self-adhesive system). After 7-day pH cycling, demineralization was assessed using Witec a300R confocal Raman microscopy. Phosphate intensity at 960 cm-1 was measured along a 130-µm enamel profile and normalized. Results: Measurements by two operators showed high intraoperator and interoperator reliability (intraclass correlation coefficient = 0.82-0.92). GC samples exhibited a continuous decline in phosphate intensity, indicating extensive demineralization, while XT samples showed a midenamel plateau, suggesting mineral preservation. Spline modeling confirmed significantly higher phosphate retention in the XT group at middepth (P < .001), with both groups showing surface demineralization near 130 µm (P = .005). Conclusions: The three-step adhesive system (Transbond XT) showed greater resistance to subsurface enamel demineralization than the self-adhesive system (GC Ortho Connect). These results suggest that using a separate primer may better protect enamel beyond the immediate bracket interface.
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