Evidence map›Paper›PMID 41759737›Full record

ArticleThe Journal of biological chemistry2026

Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intestinal epithelia leads to major alterations in glycocalyx and tumorigenesis.

Tongzhong Ju, Yingchun Wang, Hikaru Nishio, Matthew R Kudelka, Xiaodong Sun, Jianmei Wang, Junwei Zeng, Lina Song, Gizem Akkas, Volkan Adsay and 2 more

Abstract read
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In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tongzhong JuDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: Tongzhong.ju@fda.hhs.gov.
Yingchun WangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA; Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Hikaru NishioDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
Matthew R KudelkaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Xiaodong SunDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Jianmei WangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Junwei ZengDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Lina SongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.
Gizem AkkasDepartment of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Volkan AdsayDepartment of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Charles A ParkosDepartment of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Richard D CummingsDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: rcummin1@bidmc.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal mucins have extended O-glycans comprised primarily of the common Core 1 O-glycan (Galβ1-3GalNAcα1-Ser/Thr/Tyr) and its modifications. Expression of such glycans is under control of Cosmc (C1GalT1C1) that encodes a key ER molecular chaperone required for formation of active T-synthase, a Golgi enzyme that modifies the Tn antigen (GalNAcα1-Ser/Thr/Tyr - CD175) to generate a Core 1 O-glycan. We previously observed that targeted deletion of Cosmc in murine intestinal epithelial cells (IEC-Cosmc-KO mice) resulted in dysbiosis and alteration of the microbiome. Here we report a detailed description of these mutant mice and find that IEC-Cosmc-KO mice, but not WT mice, express CD175 throughout the intestinal epithelia. CD175 expression is accompanied by loss of glycocalyx, shortening of microvilli, compromised MUC2, thickening of the epithelial layer, as well as generation of high levels of reactive oxygen species. The majority of IEC-Cosmc

Indexed as

CarcinogenesisGalactosyltransferasesGlycocalyxMolecular ChaperonesAnimalsAntigens, Tumor-Associated, CarbohydrateIntestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutAntigens, Tumor-Associated, CarbohydrateCosmc protein, mouseGalactosyltransferasesMolecular ChaperonesTn antigenC1GalT1C1colon cancerCosmcglycocalyxintestinal epithelial cells (IEC)knockout mice (KO)O-glycosylationTn antigenT-synthase

Identifiers

PMID41759737
PMCPMC13049941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.