Evidence map›Paper›PMID 41759731›Full record

ArticleThe Journal of biological chemistry2026

G protein Gα

Joseph Loomis, Naincy Chandan, Michael Burroughs, Saji Abraham, Rongxi Zhang, Yiyi Cao, Matthew J Brody, Gregory G Tall, Alan V Smrcka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joseph LoomisDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA.
Naincy ChandanDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA; Nurix Therapeutics, San Franscisco, California, USA.
Michael BurroughsDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Saji AbrahamDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Rongxi ZhangDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Yiyi CaoDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Matthew J BrodyDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Gregory G TallDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.
Alan V SmrckaDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: avsmrcka@umich.edu.

Funding

Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Investigation of Adhesion GPCR and Ric-8 protein control of heterotrimeric G proteinsR35GM149539 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Gregory Gordon Tall · 2023 to 2026
$2.1M
NIGMS NIH HHS R35 GM127303NIGMS NIH HHS R35 GM149539
6 · The paper itself

Abstract

Gα

Indexed as

Cell NucleusChromatin Assembly and DisassemblyGTP-Binding Protein alpha Subunits, Gq-G11HEK293 CellsHumansGTP-Binding Protein alpha Subunits, Gq-G11chromatinG ProteinG protein-coupled receptorGqnucleusproximity labeling G protein-coupled receptor

Identifiers

PMID41759731
PMCPMC13129537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.