Evidence map›Paper›PMID 41759651›Full record

ArticleAmerican journal of ophthalmology2026

Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.

Hongyuan Zhang, Bassel Hammoud, Bianca N Susanna, Barbara A L Dutra, Giuliano Scarcelli, J Bradley Randleman

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongyuan ZhangFrom the Cole Eye Institute (H.Z., B.H., B.N.S., B.A.L.D., J.B.R.), Cleveland Clinic, Cleveland, Ohio, USA.
Bassel HammoudFrom the Cole Eye Institute (H.Z., B.H., B.N.S., B.A.L.D., J.B.R.), Cleveland Clinic, Cleveland, Ohio, USA.
Bianca N SusannaFrom the Cole Eye Institute (H.Z., B.H., B.N.S., B.A.L.D., J.B.R.), Cleveland Clinic, Cleveland, Ohio, USA; Department of Ophthalmology (B.N.S., B.A.L.D.), University of Sao Paulo, Sao Paulo, Brazil; Sorocaba Eye Hospital (B.N.S.), Sorocaba, Brazil.
Barbara A L DutraFrom the Cole Eye Institute (H.Z., B.H., B.N.S., B.A.L.D., J.B.R.), Cleveland Clinic, Cleveland, Ohio, USA; Department of Ophthalmology (B.N.S., B.A.L.D.), University of Sao Paulo, Sao Paulo, Brazil.
Giuliano ScarcelliFischell Department of Bioengineering (G.S.), University of Maryland, College Park, Maryland, USA.
J Bradley RandlemanFrom the Cole Eye Institute (H.Z., B.H., B.N.S., B.A.L.D., J.B.R.), Cleveland Clinic, Cleveland, Ohio, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (J.B.R.), Cleveland, Ohio, USA. Electronic address: randlej@ccf.org.

Funding

Cornea biomechanical analysis with Brillouin microscopyR01EY028666 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI James Bradley Randleman, Giuliano Scarcelli · 2018 to 2026
$4.1M
Determining the Efficacy of Corneal Cross-Linking Protocols using Brillouin MicroscopyR01EY032537 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI DUPPS, WILLIAM JOSEPH, RANDLEMAN, JAMES BRADLEY · 2022 to 2025
$1.6M
NEI NIH HHS R01 EY028666NEI NIH HHS R01 EY032537
6 · The paper itself

Abstract

purposeTo compare the diagnostic efficacy of motion-tracking (MT) Brillouin microscopy with multimodal corneal imaging for keratoconus suspect (KCS) identification.

designProspective, cross-sectional diagnostic evaluation.

methodsThere were 56 eyes from 56 patients evaluated, including 28 eyes from 28 bilaterally normal control patients and 28 eyes from 28 keratoconus suspect patients. All patients underwent MT Brillouin microscopy using a custom-built device, Scheimpflug tomography, anterior segment optical coherence tomography (AS-OCT), and Corneal Visualization Scheimpflug Technology (Corvis ST). MT Brillouin microscopy data included mean (MTB-mean) and focal minimum (MTB-min) values within the anterior plateau region. The sensitivity, specificity, and area under the receiver operating characteristic curves (AUROC) were calculated for variables from all modalities.

resultsNo significant demographic differences were found between groups except thinnest corneal thickness (556 μm Control vs 526 μm KCS; P < .001). MT Brillouin metrics MTB-min (AUC = 0.999, Sensitivity 100%, Specificity 96%) and MTB-mean (AUC 0.981, Sensitivity 93%, Specificity 100%) outperformed all other multimodal imaging metrics in KCS identification and group differentiation. MTB-min significantly outperformed all multimodal metrics, including the Corvis ST Tomographic and Biomechanical Index (TBI) (AUC 0.906, P = .018), Pentacam Random Forest Index (PRFI) (AUC 0.870, P = .005), Keratoconus Index (KI) (AUC 0.873, P = .005), and Index of Height Decentration (IHD) (AUC 0.859, P = .005). The best epithelial metric, Epi 5 mm ST-IN, performed poorly in group differentiation (AUC = 0.641).

conclusionsMotion-tracking Brillouin microscopy metrics effectively identified focal corneal weakening in keratoconus suspects and significantly outperformed all multimodal imaging metrics in differentiating keratoconus suspect eyes from normal controls.

Indexed as

CorneaKeratoconusMicroscopyMultimodal ImagingAdultArea Under CurveCross-Sectional StudiesFemaleHumansMaleMiddle AgedMotion CaptureProspective StudiesROC CurveSensitivity and SpecificityTomography, Optical Coherence

Identifiers

PMID41759651
PMCPMC13242640

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.