ArticleBiomedical journal2026
Comparison of tear function in patients with and without mental disorders: A systematic review and meta-analysis.
Article in Biomedical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEye care is crucial for patients with mental disorders, yet it is often overlooked. Previous studies suggest a link between mental disorders and dry eye disease, but results on objective tear function are inconsistent. This meta-analysis aimed to compare tear function between patients with and without mental disorders.
methodsWe systematically searched Embase, PubMed, Cochrane and PsycINFO up to November 19, 2025. We included studies reporting the comparison of tear function outcomes measured by the Schirmer test or tear break-up time (TBUT) between adult patients with and without mental disorders. The meta-analysis based on a random-effects model presented pooled mean differences between groups.
resultsWe included 15 studies with a total of 3,319 participants. Our meta-analysis revealed that patients with mental disorders had lower TBUT (MD: -3.72, 95% CI: -5.76 to -1.69, I
conclusionCompared to patients without mental disorders, patients with mental disorders were associated with poor tear function. Regular monitoring and early detection of tear dysfunction should be considered for patients with mental disorders. However, due to the substantial heterogeneity and the cross-sectional design of most included studies, the findings should be interpreted with caution and are best viewed as hypothesis-generating.
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