Evidence map›Paper›PMID 41759510›Full record

ArticleImmunity2026

MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species.

Domien Vanneste, Wen Peng, Zhuangzhuang Liu, Malik Hamaïdia, Raphaël La Rocca, Joan Abinet, Alexis Balthazar, Fabienne Perin, Alexandre Hego, Didier Cataldo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Domien VannesteLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. Electronic address: domien.vanneste@uliege.be.
Wen PengLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Zhuangzhuang LiuLaboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium.
Malik HamaïdiaLaboratory of Cellular and Molecular Epigenetics, GIGA Institute, University of Liège, Liège, Belgium.
Raphaël La RoccaLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Joan AbinetLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Alexis BalthazarFaculty of Veterinary Medicine, University of Liège, Liège, Belgium; Laboratory of Immunology-Vaccinology, FARAH Institute, University of Liège, Liège, Belgium.
Fabienne PerinLaboratory of Tumor and Development Biology, GIGA Institute, University of Liège, Liège, Belgium.
Alexandre HegoIn Vitro Imaging Platform, GIGA Institute, University of Liège, Liège, Belgium.
Didier CataldoLaboratory of Tumor and Development Biology, GIGA Institute, University of Liège, Liège, Belgium.
Fabrice BureauFaculty of Veterinary Medicine, University of Liège, Liège, Belgium; Laboratory of Cellular and Molecular Immunology, GIGA Institute, University of Liège, Liège, Belgium.
Philippe CompèreLaboratory of Functional and Evolutionary Morphology, FOCUS Research Unit, Department of Biology, Ecology and Evolution, University of Liège, Liège, Belgium; Center for Applied Research and Education in Microscopy (CAREM) and Biomaterials Interfaculty Center (CEIB), University of Liège, Liège, Belgium.
Bénédicte MachielsFaculty of Veterinary Medicine, University of Liège, Liège, Belgium; Laboratory of Immunology-Vaccinology, FARAH Institute, University of Liège, Liège, Belgium.
Charlotte L ScottLaboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium.
Coraline RadermeckerLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Thomas MarichalLaboratory of Immunophysiology, GIGA Institute, University of Liège, Liège, Belgium; Faculty of Veterinary Medicine, University of Liège, Liège, Belgium; Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium. Electronic address: t.marichal@uliege.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homeostatic resident tissue macrophages (RTMs) not only exhibit diversity across tissues but also share common features that are driven by conserved transcriptional programs. While the transcription factor MafB is highly expressed in macrophages, its role in establishing RTM identity and functions remains unclear. Here, we show that MafB was required for the development of bone-marrow-derived macrophages (BMDMs) and most RTMs in vivo. MafB deficiency retained RTMs in a CD52

Indexed as

MacrophagesMafB Transcription FactorAnimalsCell DifferentiationGene Expression RegulationHomeostasisHumansMiceMice, Inbred C57BLMice, KnockoutOrgan SpecificityPhagocytosisTranscription, GeneticMAFB protein, humanMafb protein, mouseMafB Transcription FactordifferentiationmacrophageMafBmonocytephagocytosistranscriptional regulationtranscription factor

Identifiers

PMID41759510
PMCPMC7618887

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.