Evidence map›Paper›PMID 41759503›Full record

ArticleArquivos de neuro-psiquiatria2026

Effects of galvanic vestibular stimulation on motor control in patients with Parkinson's disease: study protocol.

Catarina Costa Boffino, Tali Yael Holzhacker, Sonia Maria Azevedo Silva, Michael C Schubert, Flávia Doná

Abstract readClinical Trial Protocol
In one paragraph

Article in Arquivos de neuro-psiquiatria, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Catarina Costa BoffinoInstituto de Assistência Médica ao Servidor Público Estadual de São Paulo, Hospital do Servidor Público Estadual (IAMSPE-HSPE), São Paulo SP, Brazil.ORCID 0000-0001-8280-6320
Tali Yael HolzhackerUniversidade Cruzeiro do Sul, Faculdade de Fisioterapia, São Paulo SP, Brazil.ORCID 0009-0004-7864-4356
Sonia Maria Azevedo SilvaInstituto de Assistência Médica ao Servidor Público Estadual de São Paulo, Hospital do Servidor Público Estadual (IAMSPE-HSPE), Setor de Distúrbio do Movimento, São Paulo SP, Brazil.ORCID 0000-0002-9937-2175
Michael C SchubertJohns Hopkins University, School of Medicine, Department of Otolaryngology Head and Neck Surgery, Laboratory of Vestibular Neuroadaptation, Baltimore MD, United States of America.ORCID 0000-0002-5975-374X
Flávia DonáInstituto de Assistência Médica ao Servidor Público Estadual de São Paulo, Hospital do Servidor Público Estadual (IAMSPE-HSPE), São Paulo SP, Brazil.ORCID 0000-0002-9138-4438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) presents with both motor and non-motor symptoms. Postural and gait aspects, as well as the risk of falls, are important causes of morbidity and mortality in PD. The neural correlates of PD are alterations in the substantia nigra of the midbrain and, among other sites mentioned, the pontine peduncle nucleus stands out. Noninvasive neuromodulation, such as galvanic vestibular stimulation (GVS), can be used in the neural centers involved in motor control alterations in PD. Projections from the vestibular system are involved in motor control and can stimulate the basal nuclei and the pontine peduncle nucleus, as well as strengthen neural networks.To analyze the effects of GVS associated with physical-functional exercise on the motor control of PD patients.A randomized, placebo-controlled clinical trial. Participants with PD, diagnosed through the Hoehn & Yahr scale (HY) 2 or 3, will be allocated to groups. Pre- and postintervention and follow-up assessments will follow a structured protocol of physical-functional instruments, as recommended in the European Guidelines for managing people with PD. The intervention for both groups will follow the American Neurofunctional Physical Therapy Guideline for managing people with PD.It is expected that, in the experimental group, the exercises will be associated with active GVS. Finally, a descriptive and statistical analysis must be conducted to verify the effects of GVS.The study of new devices focusing on motor control in PD is a novel approach and warrants further investigation in the context of vestibular function.

Indexed as

Electric Stimulation TherapyParkinson DiseaseVestibular SystemVestibule, LabyrinthHumansRandomized Controlled Trials as TopicTreatment Outcome

Identifiers

PMID41759503
PMCPMC12948465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.