Evidence map›Paper›PMID 41759463›Full record

ArticlePoultry science2026

Portulaca oleracea L. extract repairs chicken cecal barrier damage caused by Eimeria tenella.

Junjie Li, Xihong Sun, Erjie Tian, Chuangye Li, Hengyu Fan, Wenpeng Zhao, Bianhua Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Junjie LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Xihong SunOffice of Information Technology Development and Management, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Erjie TianCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Chuangye LiCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Hengyu FanCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Wenpeng ZhaoCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China.
Bianhua ZhouCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471000, China. Electronic address: zhoubh@haust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chicken coccidiosis causes huge massive economic losses to the global poultry industry. Portulaca oleracea L. (POL) has anthelmintic, antioxidant and anti-inflammatory properties. This study aims to evaluate comprehensively the effect of POL extract (POLE) on Eimeria tenella (E. tenella) and its reparative effect on the intestinal barrier damage induced by E. tenella. Results showed that POLE had an anticoccidial index of 148.46. In chickens, E. tenella infection caused cecal swelling and bleeding and a significant increase in intestinal permeability. H&E staining demonstrated that POLE supplementation alleviated cecal structural damage, with a significant increase in villus height (VH), crypt depth (CD) and VH/CD ratio, whereas muscularis thickness (MT) significantly decreased. PAS and AB-PAS staining revealed that POLE treatment significantly increased the number of goblet cells and glycoproteins in the cecum. POLE significantly enhanced the antioxidant and anti-inflammatory capacity of chickens infected by E. tenella. The effect significantly decreased MDA content and IFN-γ and TNF-α levels and significantly increased T-AOC and GSH-Px contents. Immunofluorescence staining illustrated that POLE significantly decreased the excessive proliferation and apoptosis of cecal cells after E. tenella infection. In summary, POLE can be considered as an efficient drug against E. tenella. It can coordinate the intestinal barrier against E. tenella infections in terms of its mechanical, chemical and immune barriers. The results of this work provide a theoretical basis for research on the anticoccidial properties of POL.

Indexed as

CecumChickensCoccidiosisCoccidiostatsEimeria tenellaPlant ExtractsPortulacaPoultry DiseasesAnimal FeedAnimalsDietDietary SupplementsIntestinal Barrier FunctionMaleCoccidiostatsPlant ExtractsAnti-inflammatoryAntioxidantEimeria tenellaIntestinal barrierPortulaca oleracea L. extract

Identifiers

PMID41759463
PMCPMC12955624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.