Evidence map›Paper›PMID 41759031›Full record

ArticleACS synthetic biology2026

An Engineered Variant of

Chinmayi R Gudi, William J Neilson, Thomas J Mansell

Abstract read
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chinmayi R GudiDepartment of Chemical and Biological Engineering, Iowa State University, 618 Bissell Road, Ames, Iowa 50011, United States.
William J NeilsonDepartment of Chemical and Biological Engineering, Iowa State University, 618 Bissell Road, Ames, Iowa 50011, United States.
Thomas J MansellDepartment of Chemical and Biological Engineering, Iowa State University, 618 Bissell Road, Ames, Iowa 50011, United States.ORCID 0000-0001-8807-4570

Funding

Creating a niche for engineered live biotherapeuticsR35GM143074 · NIGMS · IOWA STATE UNIVERSITY · PI MANSELL, THOMAS J · 2021 to 2025
$1.5M
NIH MIRA R35GM143074
6 · The paper itself

Abstract

The gut microbiome and its effects on human health have generated considerable scientific, veterinary, and medical interest in recent years. Several gut bacterial species have emerged as potential chassis organisms for the delivery of therapeutics in this milieu. Among these,

Indexed as

Escherichia coliTransformation, BacterialElectroporationPlasmidsadaptive lab evolutionchassis engineeringEscherichia coli Nissle 1917probiotic engineering

Identifiers

PMID41759031
PMCPMC13010370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.