Evidence map›Paper›PMID 41758951›Full record

ArticleScience advances2026

Global maps of transcription factor properties reveal threshold-based formation of DNA-bound and mobile clusters.

Sadia Siddika Dima, Meghan A Turner, Hernan G Garcia, Gregory T Reeves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sadia Siddika DimaDepartment of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.ORCID 0009-0008-3558-9093
Meghan A TurnerBiophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2451-5036
Hernan G GarciaBiophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-5212-3649
Gregory T ReevesDepartment of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0003-0836-7766

Funding

Systems-level Analysis of Dynamics and Regulation of the Drosophila NF-kappaB/Dorsal Signaling ModuleR01GM151409 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Gregory T Reeves · 2024 to 2026
$978k
NIGMS NIH HHS R01 GM151409
6 · The paper itself

Abstract

The relationship between bulk transcription factor concentration and DNA binding has been a central question in gene regulation for decades. Recent studies propose that DNA-bound transcription factor hubs, or clusters, aid in fast and precise transcriptional interpretation. Using live imaging techniques, we quantify the concentration, binding, and mobility of the morphogen Dorsal (Dl), both in bulk and in clusters, in

Indexed as

DNADNA-Binding ProteinsDrosophila ProteinsNuclear ProteinsTranscription FactorsAnimalsBlastodermCell NucleusDrosophila melanogasterGene Expression Regulation, DevelopmentalPhosphoproteinsProtein Bindingdl protein, DrosophilaDNADNA-Binding ProteinsDrosophila ProteinsNuclear ProteinsPhosphoproteinsTranscription Factors

Identifiers

PMID41758951
PMCPMC12947891

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.