ArticleScience immunology2026
Human LFA-1 governs T cell immune surveillance of the skin.
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Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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3 citing papers in PubMed.
- A Flow Cytometry-Based Assay to Quantify the Binding of Transmembrane Ligands to Their Cognate Receptors Using Fluorescent Virus-Like Particles.Bio-protocol · 2026Article
- A flow cytometry-based assay to quantify the binding of transmembrane ligands to their cognate receptors using fluorescent virus-like particles.bioRxiv : the preprint server for biology · 2026Article
- Toward a monogenic architecture of human infections: From 1996 to 2026.Journal of human immunity · 2026Review
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Authors and funding
64 authors.
Ahmad YatimSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-4859-4085
Leila YoussefianDepartment of Pathology, Cytogenetics Laboratory, City of Hope National Medical Center, Irwindale, CA, USA.ORCID 0000-0002-4253-6503
Aida IdaniLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.ORCID 0000-0001-9418-3810
Haralambos MourelatosSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-8816-8646
Nasrin Alipour OlyaeiLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.
Laleh HabibiDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jessica N PeelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-1894-8882
Maira GaballaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
Colin KimSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-2080-0799
Danyel LeeSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0003-3124-0245
Corentin Le Floc'hLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0009-0007-0590-0437
Yi-Hao ChanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0003-0329-238X
Marta Martin-FernandezDepartment of Pediatrics and Center for Genetic Errors of Immunity, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0003-4671-6349
Léo PelletierLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0009-0001-2945-9750
Koji NakajimaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-3548-5330
Antoine FayandLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-2720-4970
Mana MomenilandiLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-5340-2762
Yoann SeeleuthnerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.
Matthieu ChaldebasSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-4920-3947
Amir Hossein SaeidianDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3512-0654
Hamidreza MahmoudiDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1890-1005
Neda NikbakhtDepartment of Dermatology and Cutaneous Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0002-9587-8689
Caroline DeswarteLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-8775-3368
Nesrine KerroucheÉtablissement Public de Santé de Proximité de Cheraga, Polyclinique de Cheraga, Department of Dermatology, Algiers, Algeria.
Houria SahelDepartment of Dermatology, CHU Bab El Oued, Faculty of Medicine, University of Algiers 1, Algiers, Algeria.ORCID 0000-0003-2056-9432
Nima ParvanehDivision of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-3397-9716
Banafshe TamizifarDermatology Clinic, Tehran, Iran.ORCID 0009-0008-8650-8812
Roya SherkatImmunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.ORCID 0000-0002-8574-2091
Johan ChanalService de Dermatologie, Hôpital Cochin-Port Royal, Paris, France.ORCID 0000-0002-8699-6755
Alireza FiroozCenter for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-7274-4840
Zahra AlizadehImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Lazaro Lorenzo-DiazLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-6648-8684
Alice-Andrée MariaggiLaboratory of Virology, Assistance Publique-Hôpitaux de Paris (AP-HP), Cochin Hospital, Paris, France.ORCID 0000-0002-1677-2967
Masato OgishiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0003-2421-7389
Antoine DiepDepartment of Immunology, Saint-Louis Hospital, Paris, France.ORCID 0000-0002-0685-1004
Boualem HammadiGeneral Chemistry Laboratory, Department of Clinical Chemistry, APHP, Necker Hospital for Sick Children, Paris, France.
Nacim KerroucheSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0009-0003-1922-9008
Darawan RinchaiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0001-8851-7730
Sahar SedighzadehDr. Shahrooei Lab, Tehran, Iran.ORCID 0000-0002-6973-4809
Soophia MehrjooyDr. Shahrooei Lab, Tehran, Iran.
Seyed Mohammad AkramiDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0003-0169-0202
Cedric LenormandDermatologic Clinic, University of Strasbourg, Strasbourg University Hospital, Strasbourg, France.ORCID 0000-0003-0501-5212
Mirjana RadosavljevicLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.ORCID 0000-0003-3925-0640
Jérémie RosainSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-2822-161X
Shen-Ying ZhangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-9449-3672
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0001-5240-3555
Peng ZhangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-6129-567X
Stéphanie Boisson-DupuisSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-7115-116X
James G KruegerLaboratory of Investigative Dermatology, Rockefeller University, New York, NY, USA.ORCID 0000-0002-3775-1778
Jean-Luc PrétetUniversité Marie et Louis Pasteur, CHU Besançon, CNRS, Chrono-environnement (UMR 6249), Besançon, France.ORCID 0000-0002-8430-214X
Tim WaterboerDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Zahra PourpakImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza FazlollahiImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1454-3933
Laurent AbelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0001-7016-6493
Dusan BogunovicDepartment of Pediatrics and Center for Genetic Errors of Immunity, Columbia University Medical Center, New York, NY, USA.ORCID 0000-0002-0683-6920
Mohammad ShahrooeiDr. Shahrooei Lab, Tehran, Iran.ORCID 0000-0002-4974-3441
Aurélie CobatSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0001-7209-6257
Raphael CarapitoLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.ORCID 0000-0002-7036-442X
Anne MolitorLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.ORCID 0000-0003-1646-2325
Hassan VahidnezhadCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-4298-9147
Vivien BéziatSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-4020-824X
Seiamak BahramLaboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, Strasbourg, France.ORCID 0000-0002-6928-9952
Emmanuelle JouanguySt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-7358-9157
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.ORCID 0000-0002-7782-4169
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MWeill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6MMolecular and cellular basis of epidermodysplasia verruciformisR01AI143810 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, JOUANGUY, EMMANUELLE · 2020 to 2024
$2.0MGenetic and immunological dissection of coinhibitory crosstalks between human T cells and cancer cellsK00CA274708 · NCI · STANFORD UNIVERSITY · PI Masato Ogishi · 2024 to 2026
$297kHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001866NCI NIH HHS K00 CA274708NIAID NIH HHS R01 AI143810NIGMS NIH HHS T32 GM152349
Abstract
The human integrin lymphocyte function-associated antigen 1 (LFA-1; αLβ2) is broadly expressed on leukocytes and involved in various intercellular adhesions. We report complete LFA-1 deficiency because of inherited αL (CD11a) deficiency in otherwise healthy adults of various ancestries with skin lesions due to commensal papillomaviruses. The patients had no history of invasive infections characteristic of children with inherited deficiency of β2 (CD18), which forms heterodimers with αL, αM (CD11b), αX (CD11c), or αD (CD11d). The development and function of leukocyte subsets are largely preserved in the absence of LFA-1. However, the transendothelial migration of skin-tropic cutaneous lymphocyte antigen (CLA)
Indexed as
Immunologic SurveillanceLymphocyte Function-Associated Antigen-1SkinT-LymphocytesAdultFemaleHumansMaleLymphocyte Function-Associated Antigen-1
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