Evidence map›Paper›PMID 41758727›Full record

ArticleNeonatology2026

Intermittent Hypoxemia and Brain Injury Biomarker S100B in Preterm Infants.

Elie G Abu Jawdeh, Linda J Van Eldik, Jennifer Stevenson, Abhijit Patwardhan, Philip M Westgate, Lina Chalak, Richard J Martin, Henrietta S Bada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neonatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Elie G Abu JawdehDepartment of Pediatrics, UT Southwestern Medical Center, and Children's Medical Center of Dallas, Dallas, Texas, USA, elie.abujawdeh@utsouthwestern.edu.
Linda J Van EldikDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Jennifer StevensonDepartment of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA.
Abhijit PatwardhanDepartment of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
Philip M WestgateDepartment of Pediatrics, Case Western Reserve University & Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Lina ChalakDepartment of Pediatrics, UT Southwestern Medical Center, and Children's Medical Center of Dallas, Dallas, Texas, USA.
Richard J MartinDepartment of Pediatrics, University of Kentucky, Lexington, Kentucky, USA.
Henrietta S BadaSanders-Brown Center on Aging and Department of Neuroscience, University of Kentucky, Lexington, Kentucky, USA.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Systemic Mediators and Biomarkers of Injury in Preterm Infants with Intermittent HypoxemiaK23HD109471 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Elie G Abu Jawdeh · 2023 to 2026
$644k
NCATS NIH HHS UL1 TR001998NICHD NIH HHS K23 HD109471
6 · The paper itself

Abstract

introductionIntermittent hypoxemia (IH) is common in preterm infants and linked to brain injury. S100B is a glial-derived protein that rises early after neural injury and can be measured noninvasively in urine. We evaluated the relationship between IH burden and urinary S100B in preterm infants of ≤32 weeks' gestation.

methodsPreterm infants of ≤32 weeks' gestation were prospectively enrolled. Oxygen saturation was continuously monitored, and IH profiles were quantified using validated algorithms. Urine S100B was measured by ultrasensitive immunoassay and normalized for urinary creatinine. Infants with severe intraventricular hemorrhage were excluded. Weighted Spearman correlations examined associations between IH metrics and urinary S100B, overall and by gestational age subgroups.

resultsTwenty-one infants contributed 53 urine samples. Higher urinary S100B correlated with greater IH frequency, percent time in hypoxemia, longer event duration, and lower nadir saturations (all p < 0.05). Short events showed the strongest correlations for frequency (ρ = 0.49) and percent time (ρ = 0.51), while longer events correlated most strongly with nadir (ρ = -0.69). Extremely preterm infants demonstrated stronger associations for nadir and duration; very preterm infants only for event severity. S100B increased stepwise across IH burden tertiles.

conclusionsUrinary S100B increases with IH burden, with patterns varying by gestational age and event duration. Urinary S100B may provide an early, noninvasive biomarker of IH-related brain injury in preterm infants.

Indexed as

BiomarkersBrain injuryIntermittent hypoxemiaPreterm infantsS100B

Identifiers

PMID41758727
PMCPMC13077789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.