Evidence map›Paper›PMID 41758688›Full record

ReviewBiochemistry2026

5,10-Methylenetetrahydrofolate Reductase─the Key Allosteric Regulator in One-Carbon Metabolism.

Linnea K M Blomgren, Shuning Guo, D Sean Froese, Thomas J McCorvie, Wyatt W Yue

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. MSTNCells · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Linnea K M BlomgrenDivision of Metabolism and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zürich CH-8008, Switzerland.ORCID 0000-0003-3833-0227
Shuning GuoBiosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.
D Sean FroeseDivision of Metabolism and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zürich CH-8008, Switzerland.
Thomas J McCorvieBiosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.ORCID 0000-0002-1502-7113
Wyatt W YueBiosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.ORCID 0000-0001-6959-6007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collectively known as one-carbon metabolism (OCM), both the folate and methionine cycles are highly regulated to meet cellular demands. These cycles are key in the production and recycling of methyl groups to be used in many essential cellular processes such as the production of nucleotides, as well as

Indexed as

CarbonMethylenetetrahydrofolate Reductase (NADPH2)Allosteric RegulationAnimalsFolic AcidHumansMethionineS-AdenosylmethionineTetrahydrofolates5,10-methylenetetrahydrofolic acidCarbonFolic AcidMethionineMethylenetetrahydrofolate Reductase (NADPH2)S-AdenosylmethionineTetrahydrofolates

Identifiers

PMID41758688
PMCPMC13001107

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.