Evidence map›Paper›PMID 41758641›Full record

ArticleSTAR protocols2026

Protocol for the formulation and characterization of extracellular vesicle-crosslinked supramolecular hydrogels.

Artemis Margaronis, James S Wang, Yara A Aguilar, Santiago Correa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Artemis MargaronisDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA. Electronic address: am6244@columbia.edu.
James S WangDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Yara A AguilarDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Santiago CorreaDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10027, USA. Electronic address: sc5159@columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) can serve as supramolecular crosslinkers to form injectable, intrinsically bioactive hydrogels. This protocol details the formulation, rheological characterization, and analysis of EV-crosslinked hydrogels with tunable mechanics. We describe steps for preparing alkyl-modified hydroxypropyl methylcellulose (HPMC) polymers, mixing polymers with EVs to form supramolecular networks, and assessing properties of the resulting hydrogels. We provide guidance for linking rheological properties to polymer-EV design parameters, enabling users to tailor hydrogel mechanics for diverse biomedical applications. For complete details on the use and execution of this protocol, please refer to Margaronis et al.

Indexed as

Extracellular VesiclesHydrogelsHypromellose DerivativesPolymersRheologyHydrogelsHypromellose DerivativesPolymersBiotechnology and bioengineeringMaterial sciencesTissue engineering

Identifiers

PMID41758641
PMCPMC12964032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.