Evidence map›Paper›PMID 41758562›Full record

Observational studyEuropean stroke journal2026

Impact of anaemia severity on functional outcome in patients with cerebral venous thrombosis: a DOAC-CVT substudy.

Nada M Sobih, Jelle Vellema, Anita van de Munckhof, Mayte Sanchez van Kammen, Xunming Ji, Ido van den Wijngaard, Jeremy Molad, Marialuisa Zedde, Y Muralidhar Reddy, Mohammad Wasay and 10 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Nada M SobihDepartment of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
Jelle VellemaDepartment of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.ORCID 0009-0002-6312-1160
Anita van de MunckhofDepartment of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
Mayte Sanchez van KammenDepartment of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
Xunming JiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0527-2852
Ido van den WijngaardDepartment of Neurology, Haaglanden Medical Center, The Hague, The Netherlands.
Jeremy MoladDepartment of Neurology, Tel Aviv Sourasky Medical center, Tel Aviv, Israel.
Marialuisa ZeddeDepartment of neurology, Azienda Unita Sanitaria Locale di Reggio Emilia, Reggio Emilia, Italy.
Y Muralidhar ReddyCARE Institute of Neurological Sciences, CARE Hospital, Banjara Hills, Hyderabad, India.
Mohammad WasayDepartment of Neurology, Aga Khan University, Karachi, Pakistan.
Antonio ArauzDepartment of Neurology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Suarez, Mexico City, Mexico.
Mirjam HeldnerDepartment of Neurology, Inselspital, University Hospital and University of Bern, Bern, Switzerland.
Nesrin ErginDepartment of Neurology, Medical Faculty, Pamukkale University, Denizli, Turkey.
Miguel A BarbozaNeurosciences Department, Hospital Dr. Rafael A. Calderón Guardia, San José, Costa Rica.
Diana Aguiar de SousaDepartment of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central - ULS São José, CEEM and Institute of Anatomy, Faculdade de Medicina da Universidade de Lisboa, Gulbenkian Institute of Molecular Medicine, Lisbon, Portugal.
Katarina JoodDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0001-8746-1771
Jukka PutaalaDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-6630-6104
Turgut TatlisumakDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jose M FerroHospital da Luz, University of Lisbon, Lisbon, Portugal.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.

Funding

Netherlands Thrombosis Foundation
6 · The paper itself

Abstract

introductionAnaemia is an established risk factor for poor outcome in intracerebral haemorrhage and ischaemic stroke. We examined whether anaemia predicts poor outcome in cerebral venous thrombosis (CVT). PATIENTS AND

methodsWe used data of the DOAC-CVT study, which was an international, prospective observational cohort study in adult patients with CVT that ran from January 2021 to January 2024. Anaemia at admission was defined according to World Health Organization criteria. Poor outcome was defined as modified Rankin Scale (mRS) 3-6 at 6-months. Binary logistic regression, adjusted for age, recent delivery/puerperium, income country, cancer and intracranial haemorrhage, was applied.

resultsOf 619 patients in DOAC-CVT, 583 patients were included, of whom 157 (27%) had anaemia. Compared to patients without anaemia, patients with anaemia were slightly younger (median age 40 vs. 42 years), more often female (76% vs. 59%), from middle income countries (36% vs. 21%), more often had intracranial haemorrhage (48% vs. 32%) and cancer (5% vs. 2%). Anaemia was associated with poor functional outcome (mRS 3-6, 10% vs. 5%, aOR: 2.20, 95% Cl, 1.01-4.81), but not with mortality (3% vs. 1%, aOR: 3.54, 95% Cl, 0.68-18.31). When stratified by severity, moderate to severe anaemia was associated with poor functional outcome (aOR 2.88, 95% Cl, 1.14-7.38), but mild anaemia was not (aOR 1.64, 95% Cl, 0.60-4.55). DISCUSSION AND

conclusionAnaemia at admission, especially moderate to severe, is a predictor for poor functional outcome in patients with CVT, highlighting the need for further studies on potential interventions.

Indexed as

AnemiaIntracranial ThrombosisVenous ThrombosisAdultFemaleHumansMaleMiddle AgedPrognosisProspective StudiesSeverity of Illness Indexanaemiacerebral venous sinus thrombosiscerebral venous thrombosisdisabilityfunctional outcomehaemoglobinprognosis

Identifiers

PMID41758562
PMCPMC12947706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.