ArticleDiscover oncology2026
Clear cell adenocarcinoma of the cervix in a perimenopausal woman: a case report and immunohistochemical study.
Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a rare case of sporadic cervical clear cell adenocarcinoma (CCAC) in a 46-year-old perimenopausal woman without the classic risk factors of in utero diethylstilbestrol (DES) exposure or high-risk human papillomavirus (HPV) infection, who presented with abnormal vaginal bleeding. Imaging revealed a bulky, barrel-shaped cervix with a large mass (measuring 4.8 × 6.7 × 3.1 cm), classified as FIGO stage IB3 based on pelvic examination and imaging findings. The patient underwent radical surgery, and the diagnosis was confirmed histologically and supported by a definitive immunohistochemical profile: the tumor was positive for PAX-8 and napsin-A, showed only partial positivity for p16, and exhibited a high Ki-67 index (70%), consistent with an HPV-independent clear cell carcinoma. This case underscores the sporadic, HPV-independent form of CCAC and highlights the critical role of immunohistochemistry in establishing the diagnosis, particularly in clinically atypical presentations.
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