ArticleCell biochemistry and biophysics2026
A Graphene Oxide-Enhanced Five-Layer Plasmonic Biosensor: Design and Theoretical Analysis for Ultrasensitive Molecular Detection.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adsorption-driven Graphene Oxide SPR Biointerfaces: Coupled Thermodynamic, Kinetic, and Optical Modeling with Effective-layer Validation.Cell biochemistry and biophysics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work presents a comprehensive theoretical investigation of a five-layer Kretschmann-configuration surface plasmon resonance (SPR) sensor for the ultrasensitive detection of the endocrine disruptor Nonylphenol. The optimized stack comprises an SF10 prism, a nanoscale TiW adhesion layer (0.2 nm), a gold film (46 nm), and a graphene oxide (GO) biorecognition layer (0.5 nm). The optical response was rigorously modelled using the transfer matrix method, while analyte capture on the GO surface has described by a Langmuir adsorption isotherm. The design achieves a deep resonance (minimum reflectance (Rmin): 0.000745) and exhibits a high angular sensitivity (S) of 95.8 deg RIU–1. Theoretical analysis predicts an exceptional Limit of Detection (LOD) of 0.054 ppb, attributable to the field-enhancing properties of GO and its high affinity for Nonylphenol via π-π stacking. This sensor performance is analyzed at low (20%) and high (50%) concentration of Nonylphenol. This sensor demonstrated excellent minimum reflectance of 0.000202 and 0.000745 respectively showing excellent detection. The Quality Factor obtained at 50% concentration of NP is 11.1 RIU–1 along with detection accuracy (DA) Figure of Merit (FOM) of ~ 6.67. The penetration depth achieved at low and high NP concentration are 182.4 and 81.6 nm respectively. This study provides a foundational model and performance benchmark for designing highly specific SPR sensors that leverage two-dimensional materials for environmental pollutant detection, establishing a clear pathway for experimental realization.
Indexed as
Identifiers
41758463What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.