Evidence map›Paper›PMID 41758446›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026

Benign vs. malignant pulmonary nodules: pleural adhesion risks and predictors.

Jiaheng Zhang, Keyue Qiu, Hang Chen, Zeyang Hu, Hongxiang Li, Zijun Xie, Guodong Xu

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Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiaheng ZhangDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Keyue QiuDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Hang ChenDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zeyang HuThe Third People's Hospital Health Care Group of Cixi, Ningbo, Zhejiang, China.
Hongxiang LiDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zijun XieDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Guodong XuDepartment of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China. xuguodong@nbu.edu.cn.ORCID http://orcid.org/0000-0001-8684-6485

Funding

Key Research and Development Program of Zhejiang Province 2024C03277(SD2)Ningbo Youth Science and Technology Innovation Leading Talents Program 2023QL055
6 · The paper itself

Abstract

backgroundDifferentiating pulmonary nodule pathology is challenging. Pleural adhesions complicate surgery, potentially relating to nodule characteristics. This study explores the correlation between nodule pathology and pleural adhesions.

methodsA single-center retrospective study included 539 patients with surgically resected pulmonary nodules. Pleural adhesions were graded, and univariate/multivariate analyses identified influencing factors. Prediction models and a nomogram were constructed.

resultsBenign nodules had a higher adhesion rate (54.8% vs. 17.6%) but mostly localized adhesions; malignant nodules had more extensive adhesions (7.2% vs. 1.6%). Age, benign nodules, and preoperative fibrinogen were independent factors. Fibrinogen alone (AUC = 0.907) and the combined model (AUC = 0.894) showed excellent predictive performance.

conclusionBenign nodules are more associated with pleural adhesions, while malignant ones cause more extensive adhesions. Age and fibrinogen are key risk factors. Fibrinogen is a reliable biomarker, and the nomogram aids individualized preoperative risk assessment.

Indexed as

Lung NeoplasmsMultiple Pulmonary NodulesPleural DiseasesSolitary Pulmonary NoduleAdultAgedFemaleFibrinogenHumansMaleMiddle AgedNomogramsRetrospective StudiesRisk FactorsTissue AdhesionsFibrinogenPleural adhesionsPulmonary nodulesRetrospective studyRisk factorsThoracic surgery

Identifiers

PMID41758446

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.