ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Intraocular pressure and corneal biomechanics in patients affected by myotonic dystrophy type 1.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo compare corneal biomechanical properties in patients affected by Myotonic Dystrophy (DM1) with healthy subjects in order to better understand the underlying reasons for low intraocular pressure (IOP) values detected in DM1 eyes.
methodsin this retrospective, comparative study were included 41 eyes of 41 DM1 patients and 41 eyes of healthy subjects, age and sex matched, were included. All participants underwent a complete eye visit including Goldmann applanation tonometry (GAT), corneal biomechanical properties evaluation performed with Corvis ST (CST) and corneal morphological evaluation through Oculus Pentacam.
resultsIn this study, GAT-measured IOP was significantly lower in DM1 patients (12.63 ± 2.12 mmHg) compared to controls (16.65 ± 2.24 mmHg) (p < 0.001). DM1 patients, compared to the healthy subjects, showed significant differences in many parameters related to the corneal deformation. In particular, DM1 patients displayed, among others, higher mean values of highest concavity deformation amplitude (1.19 mm vs. 1.04 mm) (p < 0.0008), of deflection amplitude measured at applanation 2 (0.15 mm vs. 0.11 mm) (p < 0.0008), deflection amplitude measured at highest concavity (0.98 mm vs. 0.87 mm) (p < 0.0008) and maximum length of deflection amplitude (1.05 mm vs. 0.88 mm) (p < 0.0008).
conclusionThe findings presented in this study suggest that the corneas of patients affected by DM1 are more susceptible to external stimuli than those of healthy subjects. Thus, GAT may underestimate IOP in DM1 patients due to altered corneal biomechanics.
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