Evidence map›Paper›PMID 41758375›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Therapeutic potential of prolactin-releasing anti-dopaminergic agents in experimental diabetic retinopathy model.

Kubra Peker, Ayse Ipek Akyuz Unsal, Ibrahim Meteoglu, Erol Erkan, Sinan Bekmez, Sayime Aydin Eroglu, Imran Kurt Omurlu, Turhan Dost, Buket Demirci

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kubra PekerDepartment of Ophthalmology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Ayse Ipek Akyuz UnsalDepartment of Ophthalmology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey. ipekunsal@yahoo.com.
Ibrahim MeteogluDepartment of Pathology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Erol ErkanDepartment of Ophthalmology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Sinan BekmezDepartment of Ophthalmology, Faculty of Medicine, University of Health Sciences, Dr. Behcet Uz Children Disease and Surgery Training and Research Hospital, Izmir, Turkey.
Sayime Aydin ErogluDepartment of Ophthalmology, Bakırçay University Çiğli Training and Research Hospital, Izmir, Turkey.
Imran Kurt OmurluDepartment of Biostatistics, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Turhan DostDepartment of Medical Pharmacology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Buket DemirciDepartment of Medical Pharmacology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key messagesWHAT IS KNOWN : • Anti-dopaminergic agents (metoclopramide (MCP), trimethobenzamide (TMB), and domperidone (DOM)) are used for diabetic gastroparesis, but their effects on diabetic eye are not well studied. WHAT IS NEW: • These drugs do not affect intraocular pressure or tear production in diabetic rats. • They increase retinal prolactin receptor expression and reduce VEGF and CD31 immunoreactivity, indicating modulation of angiogenesis-related markers in the diabetic retina. • These findings may encourage future research to explore the potential role of prolactin-elevating antidopaminergic agents in diabetic retinopathy.

Indexed as

Diabetes Mellitus, ExperimentalDiabetic RetinopathyDopamine AntagonistsProlactinRetinaAnimalsDisease Models, AnimalIntraocular PressureMaleRatsDopamine AntagonistsProlactinDiabetic retinopathyGastrokineticsIntraocular pressureProkineticsRational drug therapySchirmer test

Identifiers

PMID41758375
PMCPMC13197232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.