ArticleJournal of cardiovascular translational research2026
Associations of Endothelial-Related lncRNAs with Early-Onset STEMI: A Case-Control Study.
Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Early-onset ST-segment elevation myocardial infarction (STEMI) in individuals under 50 is an increasing concern. Identifying new biomarkers could improve early diagnosis and intervention. In this case-control study, we investigated endothelial-related long non-coding RNAs (lncRNAs) MANTIS, NORAD, RNCR3, and SENCR as potential diagnostic markers. Blood samples from 200 young STEMI patients and 200 age-matched controls were analyzed using real-time PCR to evaluate lncRNA expression. NORAD and MANTIS levels were significantly reduced in STEMI patients (p < 0.001). MANTIS displayed the strongest association (AUC = 0.92), while NORAD demonstrated a moderate association (AUC = 0.68). SENCR and RNCR3 showed no significant differences between groups. The downregulation of MANTIS and NORAD suggests their potential roles as biomarkers in early-onset STEMI. MANTIS, in particular, may enhance risk stratification and treatment. Further research is warranted to validate these findings in broader populations.
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