Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Head to head comparison between arterial spin labelling MRI and [
Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Abstract
background and purposeArterial Spin Labelling MRI is a neuroimaging technique able to evaluate brain perfusion, an indirect measure of brain metabolism and function. Arterial Spin Labelling MRI showed to have performances comparable to [18F]fluorodeoxyglucose-PET in in epilepsy, yet literature data is still lacking about its use in children and the value of voxel-based asymmetry index analysis. Purpose of the project is to compare the Arterial Spin Labelling MRI and [18F]fluorodeoxyglucose-PET ability to identify the epileptogenic zone before and after asymmetry index analysis in children. MATERIALS AND
methodsIn this observational study, paediatric patients with focal onset drug-resistant epilepsy that underwent presurgical evaluation, including Arterial Spin Labelling MRI and [18F]fluorodeoxyglucose-PET, were enrolled. The epileptogenic zone was defined by anatomo-electroclinical correlation and post-surgical outcome, when feasible. The rates of concordance with the epileptogenic zone of Arterial Spin Labelling MRI and [18F]fluorodeoxyglucose-PET before (visual analysis) and after asymmetry index analysis, were calculated. Statistically significant differences between were determined using Mc Nemar’s test (p < 0.05).
results28 paediatric patients (mean age 10.07 years, 15 females) with focal epilepsy were enrolled; 22 underwent epilepsy surgery (mean age 9.86 years, 12 females). When comparing the techniques, visual analysis of Arterial Spin Labelling MRI had a significantly lower rate of concordance with the epileptogenic zone (p < 0.05).
conclusionVoxel-based asymmetry index analysis increased significantly the rate of concordance of Arterial Spin Labelling MRI with the epileptogenic zone, achieving results comparable with [18F]fluorodeoxyglucose-PET in a cohort of paediatric patients.
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