Evidence map›Paper›PMID 41758076›Full record

ArticleACS sensors2026

Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.

Peter E Beshay, Zachary Osborn-King, Marissa C Kruse, Jordin T Marshall, Teng Teng, Jonathan W Song, Carlos E Castro, Benjamin A Walter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Peter E BeshayDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.
Zachary Osborn-KingDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Marissa C KruseDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0001-9514-0721
Jordin T MarshallDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0003-1241-9167
Teng TengDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0002-1172-5739
Jonathan W SongDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-6991-5298
Carlos E CastroDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-7023-6105
Benjamin A WalterDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-0742-5533

Funding

Osmotic Properties of Healthy and Degenerated Cell Pericellular MatrixR21AR076611 · NIAMS · OHIO STATE UNIVERSITY · PI WALTER, BENJAMIN A. · 2020 to 2021
$354k
NIAMS NIH HHS R21 AR076611
6 · The paper itself

Abstract

Ion gradients play a vital role in cellular signaling, mechanobiology, and organ-level homeostasis. Despite their importance, accurately mapping these spatial gradients at biologically relevant length scales remains a challenge due to the limited tunability and spatial resolution of conventional fluorescent sensors. Here, we present a DNA origami-based sensor (NanoDyn) with tunable sensitivity that enables the detection of Na

Indexed as

Biosensing TechniquesDNADNA NanostructuresNanotechnologySodiumIonsMicrofluidic Analytical TechniquesSpectrometry, FluorescenceDNAIonsSodiumconcentration gradientsDNA nanotechnologyFRETion sensingmicrofluidics

Identifiers

PMID41758076
PMCPMC13411217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.