Evidence map›Paper›PMID 41758072›Full record

ArticleInternational forum of allergy & rhinology2026

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR-F508del Rabbit Model.

Do-Yeon Cho, Alexis E McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping-Ay, Daniel M Beswick, Justin H Turner, Bradford A Woodworth, Jie Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Do-Yeon ChoDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-5173-8959
Alexis E McFeelyDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-6910-8402
Daniel SkinnerDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shaoyan ZhangDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Justin HedvatDepartment of Otolaryngology Head & Neck Surgery, University of California at Los Angeles, California, USA.
Weslee Ping-AyDepartment of Otolaryngology Head & Neck Surgery, University of California at Los Angeles, California, USA.
Daniel M BeswickDepartment of Otolaryngology Head & Neck Surgery, University of California at Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-8612-5442
Justin H TurnerDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bradford A WoodworthDepartment of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-3292-9167
Jie XuCenter For Advanced Models For Translational Sciences and Therapeutics, University of Michigan Medical Center, Michigan, USA.

Funding

Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisR01HL133006 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2016 to 2020
$1.7M
Dysbiosis of the Sinus Microbiota in Chronic RhinosinusitisK08AI146220 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2019 to 2021
$467k
Impact of mucin fermenting microbes on the virulence of Pseudomonas aeruginosa in chronic rhinosinusitisR21AI168894 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2022 to 2023
$408k
Cystic Fibrosis Foundation 002481G221Cystic Fibrosis Foundation CHO20A0-KBNCCIH NIH HHS R21AT01223-01NHLBI NIH HHS 1 R01 HL133006-05NHLBI NIH HHS R01 HL133006NIAID NIH HHS K08 AI146220NIAID NIH HHS R21 AI168894NIH HHSthe National Institute of Allergy and Infectious Diseases 1R21AI168894-01the National Institute of Allergy and Infectious Diseases K08AI146220Triological Society Career Development Award, and Cystic Fibrosis Foundation CHO20A0-KB
6 · The paper itself

Abstract

backgroundChronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk for CRS; however, the sinonasal phenotype and host-pathogen interactions in CF carriers remain poorly defined.

methodsWe characterized heterozygous ΔF508 CF rabbits (heterozygous, n = 6) compared with wild-type (WT) (n = 5). Baseline sinonasal structure was assessed by computed tomography and histology. CFTR function was measured by nasal potential difference (NPD) and Ussing chamber analysis of primary epithelial cultures, with or without CFTR modulators. Bacterial sinusitis was induced using Pseudomonas aeruginosa (PA14), followed by longitudinal imaging, bacterial quantification, histology, and PA14 RNA sequencing.

resultsHeterozygous rabbits demonstrated significant sinus hypoplasia compared with WT (mm

conclusionsHeterozygous ΔF508 CF rabbits recapitulate key sinonasal features relevant to CF carriers, including reduced CFTR function, altered host defense, and impaired infection clearance. This model provides a translational platform for investigating CRS pathogenesis and evaluating CFTR-targeted therapies in CF carriers.

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorPseudomonas InfectionsRhinosinusitisSinusitisAnimalsChronic DiseaseDisease Models, AnimalHeterozygoteMutationParanasal SinusesPseudomonas aeruginosaRabbitsCystic Fibrosis Transmembrane Conductance Regulatoranimal modelCF carrierCFTRcystic fibrosisphenotyperabbit modelrhinosinusitis

Identifiers

PMID41758072
PMCPMC13432446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.