resaCPE: a rapid, low-cost colorimetric assay for the detection of carbapenemase-producing Enterobacterales.

Mitchell A Jeffs, Gabhan Chalmers, Henry Wong, Prameet M Sheth, Nicole Ricker, Christopher T Lohans

Abstract readEvaluation Study

In one paragraph

Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mitchell A JeffsDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Gabhan ChalmersDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Henry WongDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.

Prameet M ShethDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Nicole RickerDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0001-5706-5399

Christopher T LohansDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0003-1094-0349

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2020-04274

6 · The paper itself

Abstract

The use of carbapenem antibiotics is threatened by the global spread of carbapenemase-producing Enterobacterales (CPE), bacterial pathogens which hydrolyze these last-resort antimicrobials. Rapid detection of CPE is vital to ensure timely administration of antimicrobial therapy to infected patients, as well as the implementation of infection control measures to prevent outbreaks in healthcare settings. In this study, we report the development of resaCPE, a rapid, low-cost CPE detection method that couples the inactivation of an imipenem disk with a cell viability assay employing a carbapenem-hypersusceptible

Indexed as

Bacterial ProteinsBacteriological Techniquesbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeColorimetryEnterobacteriaceaeEnterobacteriaceae InfectionsAnti-Bacterial AgentsCarbapenemsHumansMicrobial Sensitivity TestsRapid Diagnostic TestsSensitivity and SpecificityTime FactorsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsantibiotic resistancecarbapenemasediagnosticphenotypic assayβ-lactamase

Identifiers

PMID41758051

DOI10.1128/jcm.01003-25

PMCPMC13059814

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.