Evidence map›Paper›PMID 41757982›Full record

Trial reportJournal of clinical microbiology2026

Serology as an early diagnostic tool in pediatric patients with Shiga toxin-producing

Stella M Landivar, Luciano J Melli, Mariana Pichel, Marta Rivas, Mariana Colonna, Carolina Massa, Vanesa Zylberman, Santiago Sanguineti, Linus Spatz, Fernando Goldbaum and 4 more

Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05569746 (A Phase II Study to Assess Safety, Efficacy, and Pharmacokinetics of INM004), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05569746 phase2completednot on this map

A Phase II Study to Assess Safety, Efficacy, and Pharmacokinetics of INM004 (Anti-Shiga Toxin) in Pediatric Patients With Hemolytic Uremic Syndrome Associated With Shiga Toxin-producing Escherichia Coli Infection

TypeinterventionalSponsorInmunova S.A.Ran2022 to 2023Enrolled57ConditionsDiarrhea-Associated Hemolytic Uremic Syndrome, Pediatric Kidney Disease, Hemolytic-Uremic SyndromeArmsINM004, SoC
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetically negative aHUS and the possibility of undetected STEC-HUS.Pediatric nephrology (Berlin, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stella M LandivarInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.
Luciano J MelliInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.
Mariana PichelInmunova S. A., San Martín, Argentina.
Marta RivasInmunova S. A., San Martín, Argentina.
Mariana ColonnaInmunova S. A., San Martín, Argentina.
Carolina MassaInmunova S. A., San Martín, Argentina.
Vanesa ZylbermanInmunova S. A., San Martín, Argentina.
Santiago SanguinetiInmunova S. A., San Martín, Argentina.
Linus SpatzInmunova S. A., San Martín, Argentina.
Fernando GoldbaumInmunova S. A., San Martín, Argentina.
Diego J ComerciInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.
Juan E UgaldeInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.ORCID 0000-0002-8301-8091
Andrés E CiocchiniInstituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (UNSAM)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.ORCID 0000-0001-7741-2562
INM004 Study Group

Funding

Agencia Nacional de Promoción Científica y Tecnológica PICT-2018-04672
6 · The paper itself

Abstract

The specific anti-O polysaccharide antibody response in Shiga toxin-producing IMPORTANCE: This study evaluated, for the first time, the dynamics of serogroup-specific IgM and IgG anti-O polysaccharide antibody response in 55 Shiga toxin-producing CLINICAL TRIALS: This study was registered with ClinicalTrials.gov as NCT05569746.

Indexed as

Antibodies, BacterialEscherichia coli InfectionsHemolytic-Uremic SyndromeSerologic TestsShiga-Toxigenic Escherichia coliChildChild, PreschoolEarly DiagnosisFemaleHumansImmunoglobulin GImmunoglobulin MInfantMaleO AntigensAntibodies, BacterialImmunoglobulin GImmunoglobulin MO AntigensdiagnosticELISAglycoproteinhemolytic uremic syndromeLFIAphase 2 clinical trialserodiagnosisSTEC

Identifiers

PMID41757982
PMCPMC13059726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.