ArticleMicrobiology spectrum2026
Evolutionary dynamics of endogenous densoviruses NS1 proteins reveal ancient codivergence with their Platyhelminth hosts.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Endogenous viral elements serve as molecular fossils of ancient viral infections, providing valuable evidence for reconstructing the evolutionary history of modern viruses and their hosts. These genomic remnants also provide crucial benchmarks for calibrating viral evolutionary timelines. Here, our flanking sequence analysis reveals that densovirus NS1 sequences are chromosomally integrated in Platyhelminth genomes. Furthermore, their evolutionary dynamics reflect an ancient host-virus codivergence event dating to the Ediacaran-Cambrian transition (approximately 692 million years ago, MYA). Phylogenomic analyses delineate profound divergence between endogenous densovirus sequences in Platyhelminthes and exogenous Parvoviridae sequences, with distinct phylogenetic clustering supporting long-term endogenization. Structural alignments reveal significant global divergence (RMSD: 15.048-36.725 Å) yet striking local conservation in NS1 proteins, with the ATPase (RMSD: 0.271-1.756 Å) and effector domains (RMSD: 2.446-4.775 Å) remaining highly conserved across Platyhelminth hosts. The timescale phylogenetic tree inferred ancient divergence times of 233.51 MYA for
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