Evidence map›Paper›PMID 41757924›Full record

ArticleJournal of bacteriology2026

Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm in

Chihiro C Yamaguchi, Robert A Kanaly, Eri Nishizaki, Keiichi Yamashita, Koichiro Takatsuki, Yoshihiko Furuike, Mingxu Fang, Shuji Akiyama, Setsuyuki Aoki, Masaki Tsukamoto and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chihiro C YamaguchiDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.
Robert A KanalyDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.ORCID 0000-0002-8867-3546
Eri NishizakiDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.
Keiichi YamashitaDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.
Koichiro TakatsukiDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.
Yoshihiko FuruikeDivision of Trans-Hierarchical Molecular Systems, Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science, National Institutes of Natural Sciences, Okazaki, Japan.
Mingxu FangCenter for Circadian Biology, University of California, San Diego, La Jolla, California, USA.
Shuji AkiyamaDivision of Trans-Hierarchical Molecular Systems, Research Center of Integrative Molecular Systems (CIMoS), Institute for Molecular Science, National Institutes of Natural Sciences, Okazaki, Japan.
Setsuyuki AokiGraduate School of Informatics, Nagoya University, Nagoya, Aichi, Japan.
Masaki TsukamotoGraduate School of Informatics, Nagoya University, Nagoya, Aichi, Japan.
Yoichi NakahiraCollege of Agriculture, Ibaraki University, Ami, Ibaraki, Japan.
Susan S GoldenCenter for Circadian Biology, University of California, San Diego, La Jolla, California, USA.
Shinsuke KutsunaDepartment of Life and Environmental System Science, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Kanagawa, Japan.ORCID 0000-0003-2671-4645

Funding

Undergraduate Summer Research Experience: Molecular and cellular mechanisms of circadian timekeeping in a prokaryote modelR35GM118290 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDEN, SUSAN S · 2016 to 2025
$6.7M
Japan Science and Technology Agency JPMJSP2179Japan Society for the Promotion of Science 17K00555Japan Society for the Promotion of Science 22H04984Japan Society for the Promotion of Science 23K05013Japan Society for the Promotion of Science 24H02301NIH HHS R35GM118290YOKOHAMA ACADEMIC FOUNDATION 2022
6 · The paper itself

Abstract

In phototrophic cyanobacteria, the signaling molecule bis-(3'-5')-cyclic dimeric-guanosine monophosphate (c-di-GMP) plays important roles in a wide variety of functions associated with environmental conditions, including biofilm formation, motility, heterocyst development, cell size control, phototaxis, and flocculation. However, its role in circadian rhythms, which contribute to fitness under diel light conditions, remains unexplored. In this study, we investigated the impact of changes in intracellular c-di-GMP levels on the circadian clock of the model cyanobacterium

Indexed as

Circadian RhythmCyclic GMPSynechococcusBacterial ProteinsEscherichia coli ProteinsGene Expression Regulation, BacterialLightPhosphorus-Oxygen LyasesSignal TransductionBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsPhosphorus-Oxygen Lyasesc-di-GMPcircadian clockcyanobacteriaSynechococcus elongatusydeHyhjH

Identifiers

PMID41757924
PMCPMC13001216

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.